2. Gene
  3. Mme - membrane metallo endopeptidase Gene

Mme - membrane metallo endopeptidase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NEP; SFE; CD10; CALLA; 6030454K05Rik

Gene ID: 17380 | Gene type: protein coding

About Mme

Summary

Enables peptidase activity. Involved in amyloid-beta clearance; positive regulation of long-term synaptic potentiation; and sensory perception of pain. Acts upstream of or within amyloid-beta metabolic process. Located in several cellular components, including dendrite; neuron projection terminus; and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and mammary gland. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Mme Products(4)

mRNA Protein Name
NM_001289462.1 NP_001276391.1 neprilysin
NM_001289463.1 NP_001276392.1 neprilysin
NM_001357335.1 NP_001344264.1 neprilysin
NM_008604.4 NP_032630.2 neprilysin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IDA
IDA: Inferred from direct assay
15944124 MGI
Biological Process GO Annotation Evidence Reference Source
involved in amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
16636059 MGI
acts upstream of or within amyloid-beta metabolic process IDA
IDA: Inferred from direct assay
12074840 MGI
involved in positive regulation of long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
16636059 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
9751784 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
12074840 MGI
located in dendrite IDA
IDA: Inferred from direct assay
12074840 MGI
located in membrane IDA
IDA: Inferred from direct assay
15944124 MGI
located in neuron projection terminus IDA
IDA: Inferred from direct assay
12074840 MGI
located in synapse IDA
IDA: Inferred from direct assay
12074840 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
12074840 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neprilysin

atriopeptidase

common acute lymphoblastic leukemia antigen

enkephalinase

neutral endopeptidase 24.11

skin fibroblast elastase

Recombinant Mme Proteins

Cat. No. Product Name Accession Purity
HY-P72878 MME Protein, Mouse (HEK293, His) Q61391/NP_032630.2 (Y52-W750) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08513 MME Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-165037 1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mme NCBI NCBI:4311
Canis familiaris Mme NCBI NCBI:477120
Macaca fascicularis Mme NCBI NCBI:101925772
Rattus norvegicus Mme NCBI NCBI:24590
Macaca mulatta Mme NCBI NCBI:707667