2. Gene
  3. Mme - membrane metallo-endopeptidase Gene

Mme - membrane metallo-endopeptidase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Nep; SFE; CD10

Gene ID: 24590 | Gene type: protein coding

About Mme

Summary

Enables oligopeptidase activity and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; animal organ development; and proteolysis. Located in plasma membrane. Used to study diarrhea and hypertension. Biomarker of Alzheimer's disease; congestive heart failure; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Mme Products(1)

mRNA Protein Name
NM_012608.2 NP_036740.1 neprilysin
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables oligopeptidase activity IDA
IDA: Inferred from direct assay
3522576 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
15308303 RGD
Biological Process GO Annotation Evidence Reference Source
involved in amyloid-beta clearance IDA
IDA: Inferred from direct assay
19406747 RGD
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: Inferred from mutant phenotype
18941241 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
1547865 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
1547865 RGD
involved in peptide metabolic process IMP
IMP: Inferred from mutant phenotype
10642323 RGD
involved in placenta development IEP
IEP: Inferred from expression pattern
1547865 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
15308303 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
15308303 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neprilysin

atriopeptidase

enkephalinase

membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase)

neutral endopeptidase 24.11

skin fibroblast elastase

Recombinant Mme Proteins

Cat. No. Product Name Accession Purity
HY-P73746 Neprilysin/CD10 Protein, Rat (HEK293, His) P07861 (Y52-W750) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08513 MME Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-165037 1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mme NCBI NCBI:4311
Canis familiaris Mme NCBI NCBI:477120
Macaca fascicularis Mme NCBI NCBI:101925772
Mus musculus Mme NCBI NCBI:17380
Macaca mulatta Mme NCBI NCBI:707667