2. Gene
  3. Mttp - microsomal triglyceride transfer protein Gene

Mttp - microsomal triglyceride transfer protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MTP; 1810043K16Rik

Gene ID: 17777 | Gene type: protein coding

About Mttp

Chromosome 3: 137,795,615-137,850,729 reverse strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 210 orthologues and is associated with 20 phenotypes. Biased expression in large intestine adult (RPKM 62.5), duodenum adult (RPKM 33.4) and 6 other tissues.

Summary

Enables Cholesterol transfer activity; phosphatidylethanolamine transfer activity; and triglyceride transfer activity. Acts upstream of or within several processes, including Cholesterol homeostasis; lipoprotein transport; and low-density lipoprotein particle remodeling. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in gut; liver; placenta; septum transversum hepatic component; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2022]

Mttp Products(4)

mRNA Protein Name
NM_008642.3 NP_032668.2 microsomal triglyceride transfer protein large subunit isoform 2 precursor
NM_001163457.2 NP_001156929.1 microsomal triglyceride transfer protein large subunit isoform 1 precursor
NM_001355051.1 NP_001341980.1 microsomal triglyceride transfer protein large subunit isoform 2 precursor
NM_001355052.1 NP_001341981.1 microsomal triglyceride transfer protein large subunit isoform 2 precursor

Mttp Protein Structure

Vitellogenin_N

Vitellogenin_N: cl44413 (27 - 578)

MTP_lip_bd

MTP_lip_bd: pfam19444 (590 - 884)

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  • 894 a.a.
Protein Preferred Names Protein Names

microsomal triglyceride transfer protein large subunit

microsomal triglyceride transfer protein B

microsomal triglyceride transfer protein, large subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08822 MTTP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08823 Mttp Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08824 Mttp Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mttp NCBI NCBI:4547