Mttp - microsomal triglyceride transfer protein Gene

Mus musculus

Also known as MTP; 1810043K16Rik

Gene ID: 17777 | Gene type: protein coding

About Mttp

Chromosome 3: 137,795,615-137,850,729 reverse strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 210 orthologues and is associated with 20 phenotypes. Biased expression in large intestine adult (RPKM 62.5), duodenum adult (RPKM 33.4) and 6 other tissues.

Summary

Enables Cholesterol transfer activity; phosphatidylethanolamine transfer activity; and triglyceride transfer activity. Acts upstream of or within several processes, including Cholesterol homeostasis; lipoprotein transport; and low-density lipoprotein particle remodeling. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in gut; liver; placenta; septum transversum hepatic component; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2022]

Mttp Products(4)

mRNA	Protein	Name
NM_008642.3	NP_032668.2	microsomal triglyceride transfer protein large subunit isoform 2 precursor
NM_001163457.2	NP_001156929.1	microsomal triglyceride transfer protein large subunit isoform 1 precursor
NM_001355051.1	NP_001341980.1	microsomal triglyceride transfer protein large subunit isoform 2 precursor
NM_001355052.1	NP_001341981.1	microsomal triglyceride transfer protein large subunit isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholesterol transfer activity	IDA IDA: Inferred from direct assay	15897609	MGI
enables lipid transporter activity	IDA IDA: Inferred from direct assay	12072432	MGI
enables phosphatidylethanolamine transfer activity	IDA IDA: Inferred from direct assay	15897609	MGI
enables phospholipid transfer activity	IDA IDA: Inferred from direct assay	33168624	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	33168624	MGI
enables triglyceride transfer activity	IDA IDA: Inferred from direct assay	15897609	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	10713055	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	24353284	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	10713055	MGI
acts upstream of or within lipid metabolic process	IDA IDA: Inferred from direct assay	12072432	MGI
acts upstream of or within lipoprotein metabolic process	IMP IMP: Inferred from mutant phenotype	10713055	MGI
acts upstream of or within lipoprotein transport	IMP IMP: Inferred from mutant phenotype	10713055	MGI
acts upstream of or within low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	27471003	MGI
acts upstream of or within protein lipidation	IDA IDA: Inferred from direct assay	12072432	MGI
acts upstream of or within triglyceride metabolic process	IDA IDA: Inferred from direct assay	12072432	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	33168624	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mttp Protein Structure

Vitellogenin_N

MTP_lip_bd

0
200
400
600
800
894 a.a.

Protein Preferred Names

Protein Names

microsomal triglyceride transfer protein large subunit

microsomal triglyceride transfer protein B

microsomal triglyceride transfer protein, large subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08822	MTTP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08823	Mttp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08824	Mttp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mttp	NCBI	NCBI:4547

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