Nf2 - neurofibromin 2 Gene

Mus musculus

Also known as merlin

Gene ID: 18016 | Gene type: protein coding

About Nf2

Summary

Predicted to enable beta-catenin binding activity; Integrin binding activity; and protein domain specific binding activity. Involved in lens fiber cell differentiation. Acts upstream of or within several processes, including negative regulation of MAPK cascade; negative regulation of protein kinase activity; and nervous system development. Located in several cellular components, including adherens junction; cleavage furrow; and ruffle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study familial meningioma; neurofibromatosis; otitis media; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Apr 2022]

Nf2 Products(8)

mRNA	Protein	Name
NM_001252250.1	NP_001239179.1	merlin isoform 1
NM_001252251.1	NP_001239180.1	merlin isoform 1
NM_001252252.1	NP_001239181.1	merlin isoform 3
NM_001252253.1	NP_001239182.1	merlin isoform 4
NM_001361675.1	NP_001348604.1	merlin isoform 5
NM_001361676.1	NP_001348605.1	merlin isoform 6
NM_001361677.1	NP_001348606.1	merlin isoform 7
NM_010898.4	NP_035028.2	merlin isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12695331	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	16405865	MGI
acts upstream of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	10887156	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	23863479	MGI
acts upstream of or within cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	12695331	MGI
acts upstream of or within ectoderm development	IMP IMP: Inferred from mutant phenotype	9171370	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	23863479	MGI
involved in lens fiber cell differentiation	IMP IMP: Inferred from mutant phenotype	20181838	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	9171370	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	16405865	MGI
acts upstream of or within negative regulation of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	10887156	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9553042	MGI
acts upstream of or within negative regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	10887156	MGI
acts upstream of or within negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	14580336	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	16405865	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	10887156	MGI
acts upstream of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	10887156	MGI
acts upstream of or within positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	23863479	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12695331	MGI
acts upstream of or within regulation of gliogenesis	IMP IMP: Inferred from mutant phenotype	25433207	MGI
acts upstream of or within regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	23863479	MGI
acts upstream of or within regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	25433207	MGI
acts upstream of or within regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	23863479	MGI
acts upstream of or within regulation of protein stability	IMP IMP: Inferred from mutant phenotype	23863479	MGI
acts upstream of or within regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	25433207	MGI
acts upstream of or within regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	25433207	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IMP IMP: Inferred from mutant phenotype	12695331	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	23863479	MGI
located in cell body	IDA IDA: Inferred from direct assay	25433207	MGI
located in cleavage furrow	IDA IDA: Inferred from direct assay	9631655	MGI
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	15467741	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	8547603	MGI
located in cytoskeleton	IDA IDA: Inferred from direct assay	15467741	MGI
located in filopodium	IDA IDA: Inferred from direct assay	9563848	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	9563848	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	25433207	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15133494	MGI
located in ruffle	IDA IDA: Inferred from direct assay	9563848	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

merlin

moesin-ezrin-radixin-like protein	neurofibromatosis 2
schwannomin

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134955	VT103	Inhibitor	99.64%	Unkown
HY-155309	LM-41	Inhibitor	99.82%	Unkown
HY-158342	PROTAC TEAD degrader-1	Degrader	/	Unkown
HY-155310	AF-2112	Inhibitor	99.82%	Unkown
HY-163644	VT-105	Inhibitor	99.93%	Unkown
HY-113821	1-Naphthyl phosphate potassium salt	Inhibitor	/	Unkown
HY-162012	HC-258		/	Unkown
HY-RS09234	NF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nf2	NCBI	NCBI:4771
Macaca fascicularis	Nf2	NCBI	NCBI:102139594

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