Nfkb2 - nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Gene

Mus musculus

Also known as lyt; p49; p52; p50B; p49/p100; NF-kappaB2

Gene ID: 18034 | Gene type: protein coding

About Nfkb2

Chromosome 19: 46,292,759-46,300,824 forward strand.GRCm39:CM001012.3

This gene has 8 transcripts (splice variants), 125 orthologues, 4 paralogues and is associated with 125 phenotypes. Broad expression in spleen adult (RPKM 67.), mammary gland adult (RPKM 33.7) and 15 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; follicular dendritic cell differentiation; and germinal center formation. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; musculature; thymus primordium; and trigeminal ganglion. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb2 Products(3)

mRNA	Protein	Name
NM_001177369.1	NP_001170840.1	nuclear factor NF-kappa-B p100 subunit isoform a
NM_001177370.1	NP_001170841.1	nuclear factor NF-kappa-B p100 subunit isoform b
NM_019408.3	NP_062281.1	nuclear factor NF-kappa-B p100 subunit isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	22880094	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17254973	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	10586052	MGI
acts upstream of or within follicular dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	10586052	MGI
acts upstream of or within germinal center formation	IMP IMP: Inferred from mutant phenotype	10586052	MGI
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23583643	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	10586052	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10402669	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nfkb2 Protein Structure

RHD-n_NFkB2

IPT_NFkappaB

PHA03095

ANK

Death_NFkB2_p100

0
200
400
600
800
899 a.a.

Protein Preferred Names

Protein Names

nuclear factor NF-kappa-B p100 subunit

DNA-binding factor KBF2

NF kappaB2

Nfkb2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nfkb2	Q9WTK5	Relb	Mus musculus	Q04863	Y2H Array	20211142
Intra	Nfkb2	Q9WTK5	Rela	Mus musculus	Q04207	Y2H Array	20211142

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3229	SN52	Inhibitor	99.82%	Unkown
HY-149351	NF-κB-IN-10	Inhibitor	/	Unkown
HY-RS09257	NFKB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09258	Nfkb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09259	Nfkb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfkb2	NCBI	NCBI:4791

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