Ninj1 - ninjurin 1 Gene

Mus musculus

Gene ID: 18081 | Gene type: protein coding

About Ninj1

Summary

Enables cell-cell adhesion mediator activity and lipopolysaccharide binding activity. Involved in several processes, including leukocyte chemotaxis; pericyte cell migration; and positive regulation of osteoclast development. Acts upstream of or within hyaloid vascular plexus regression and positive regulation of cell-matrix adhesion. Located in extracellular region; filopodium membrane; and synaptic membrane. Is integral component of plasma membrane. Is expressed in several structures, including body cavity or lining; central nervous system; eye; genitourinary system; and vertebral axis musculature. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Apr 2022]

Ninj1 Products(1)

mRNA	Protein	Name
NM_013610.3	NP_038638.1	ninjurin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion mediator activity	IDA IDA: Inferred from direct assay	24347169	MGI
enables cell-cell adhesion mediator activity	IMP IMP: Inferred from mutant phenotype	25766274	MGI
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	26677008	MGI
enables membrane destabilizing activity	IDA IDA: Inferred from direct assay	33472215	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	24917672	MGI
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	24347169	MGI
involved in cellular hyperosmotic response	IDA IDA: Inferred from direct assay	37980412	MGI
involved in chemotaxis	IDA IDA: Inferred from direct assay	23142597	MGI
involved in cytolysis	IDA IDA: Inferred from direct assay	33472215	MGI
involved in ferroptosis	IDA IDA: Inferred from direct assay	38396301	MGI
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	25766274	MGI
acts upstream of or within hyaloid vascular plexus regression	IMP IMP: Inferred from mutant phenotype	19557008	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	24347169	MGI
involved in leukocyte chemotaxis involved in inflammatory response	IDA IDA: Inferred from direct assay	24917672	MGI
involved in leukocyte chemotaxis involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	30510259	MGI
involved in macrophage chemotaxis	IDA IDA: Inferred from direct assay	24917672	MGI
involved in muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	31091274	MGI
involved in pericyte cell migration	IMP IMP: Inferred from mutant phenotype	25766274	MGI
acts upstream of or within positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	19557008	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	26677008	MGI
involved in positive regulation of osteoclast development	IMP IMP: Inferred from mutant phenotype	30700695	MGI
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	25860173	MGI
involved in programmed necrotic cell death	IDA IDA: Inferred from direct assay	37980412	MGI
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	24917672	MGI
involved in pyroptotic cell death	IDA IDA: Inferred from direct assay	36468682	MGI
involved in regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	25766274	MGI
involved in regulation of monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	32883094	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	23142597	MGI
located in filopodium membrane	IDA IDA: Inferred from direct assay	24917672	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	38396301	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	27815839	MGI
located in synaptic membrane	IDA IDA: Inferred from direct assay	27815839	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ninjurin-1

nerve injury-induced protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09298	NINJ1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ninj1	NCBI	NCBI:4814
Rattus norvegicus	Ninj1	NCBI	NCBI:25338

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