Nrp2 - neuropilin 2 Gene

Mus musculus

Also known as Np2; Np-2; Npn2; Npn-2; 1110048P06Rik

Gene ID: 18187 | Gene type: protein coding

About Nrp2

Summary

Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and neural crest cell migration. Located in axon. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and limb. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Nrp2 Products(6)

mRNA	Protein	Name
NM_001077403.1	NP_001070871.1	neuropilin-2 isoform 1 precursor
NM_001077404.1	NP_001070872.1	neuropilin-2 isoform 2 precursor
NM_001077405.1	NP_001070873.1	neuropilin-2 isoform 4 precursor
NM_001077406.1	NP_001070874.1	neuropilin-2 isoform 5 precursor
NM_001077407.1	NP_001070875.1	neuropilin-2 isoform 6 precursor
NM_010939.2	NP_035069.2	neuropilin-2 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10520994	MGI
enables semaphorin receptor activity	IDA IDA: Inferred from direct assay	15239958	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	22790009	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15814794	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in dorsal root ganglion morphogenesis	IMP IMP: Inferred from mutant phenotype	19386662	MGI
involved in facial nerve structural organization	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in facioacoustic ganglion development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IMP IMP: Inferred from mutant phenotype	21059704	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	12852851	MGI
acts upstream of or within negative chemotaxis	IGI IGI: Inferred from genetic interaction	16319111	MGI
acts upstream of or within negative chemotaxis	IMP IMP: Inferred from mutant phenotype	15814794	MGI
involved in nerve development	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in neural crest cell migration involved in autonomic nervous system development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	21059704	MGI
involved in outflow tract septum morphogenesis	IGI IGI: Inferred from genetic interaction	26053665	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	20010807	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	20010807	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in sensory neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18356247	MGI
involved in sympathetic ganglion development	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in sympathetic neuron projection extension	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in sympathetic neuron projection guidance	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in trigeminal ganglion development	IMP IMP: Inferred from mutant phenotype	18356247	MGI
acts upstream of or within trunk neural crest cell migration	IMP IMP: Inferred from mutant phenotype	16319111	MGI
involved in ventral trunk neural crest cell migration	IMP IMP: Inferred from mutant phenotype	19386662	MGI
involved in vestibulocochlear nerve structural organization	IMP IMP: Inferred from mutant phenotype	18356247	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	15677725	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20010807	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20010807	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	25143608	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuropilin-2

vascular endothelial cell growth factor 165 receptor 2

Recombinant Nrp2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73315	Neuropilin-2 Protein, Mouse (HEK293, His)	O35375 (M1-P864)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990782	Efzofitimod		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09580	NRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nrp2	NCBI	NCBI:8828

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