2. Gene
  3. NRP2 - neuropilin 2 Gene

NRP2 - neuropilin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NP2; NPN2; PRO2714; VEGF165R2

Gene ID: 8828 | Gene type: protein coding

About NRP2

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:205,682,501-205,798,131 (from NCBI)

This gene has 17 transcripts (splice variants), 285 orthologues and 35 paralogues. Broad expression in placenta (RPKM 10.6), ovary (RPKM 9.8) and 20 other tissues.

Summary

This gene encodes a member of the neuropilin family of Receptor Proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]

NRP2 Products(6)

mRNA Protein Name
NM_003872.3 NP_003863.2 neuropilin-2 isoform 2 precursor
NM_018534.4 NP_061004.3 neuropilin-2 isoform 4 precursor
NM_201264.2 NP_957716.1 neuropilin-2 isoform 6 precursor
NM_201266.2 NP_957718.1 neuropilin-2 isoform 1 precursor
NM_201267.2 NP_957719.1 neuropilin-2 isoform 5 precursor
NM_201279.2 NP_958436.1 neuropilin-2 isoform 3 precursor

NRP2 Protein Structure

CUB

CUB: CUB domain (28 - 139)

CUB

CUB: CUB domain (149 - 264)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (292 - 424)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (449 - 589)

MAM

MAM: MAM domain, meprin/A5/mu (646 - 800)

DUF3481

DUF3481: C-terminal domain of neuropilin glycoprotein (861 - 928)

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  • 931 a.a.
Protein Preferred Names Protein Names

neuropilin-2

neuropilin-2a(17)

Recombinant NRP2 Proteins

Cat. No. Product Name Accession Purity
HY-P73313 Neuropilin-2 Protein, Human (HEK293, Fc) O60462 (Q23-Y855) ≥95%
HY-P73314 Neuropilin-2 Protein, Human (855a.a, HEK293, His) O60462 (Q23-P859) ≥95%

Related Diseases

Diseases Alias
Lymphangioma

Lymphatic Malformation

Lymphatic Malformations

Benign Lymphangioma

Congenital Lymphangioma

Lymphangiomas
Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hereditary Lymphedema

Milroy Disease
Hereditary Lymphedema I

Lymphedema

Hereditary Lymphedema Type I

Congenital Primary Lymphedema

Lmph1

Milroy Disease

Nonne-Milroy Lymphedema

Pcl

Lymphedema Hereditary Type 1
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09580 NRP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990782 Efzofitimod / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NRP2 RGD RGD:621442
Bos taurus NRP2 VGNC VGNC:32267
Mus musculus NRP2 MGD MGI:1100492
Canis familiaris NRP2 VGNC VGNC:43975
Macaca mulatta NRP2 VGNC VGNC:75533
Felis catus NRP2 VGNC VGNC:68570
Others NRP2 NCBI