NRP2 - neuropilin 2 Gene

Homo sapiens

Also known as NP2; NPN2; PRO2714; VEGF165R2

Gene ID: 8828 | Gene type: protein coding

About NRP2

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:205,682,501-205,798,131 (from NCBI)

This gene has 17 transcripts (splice variants), 285 orthologues and 35 paralogues. Broad expression in placenta (RPKM 10.6), ovary (RPKM 9.8) and 20 other tissues.

Summary

This gene encodes a member of the neuropilin family of Receptor Proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]

NRP2 Products(6)

mRNA	Protein	Name
NM_003872.3	NP_003863.2	neuropilin-2 isoform 2 precursor
NM_018534.4	NP_061004.3	neuropilin-2 isoform 4 precursor
NM_201264.2	NP_957716.1	neuropilin-2 isoform 6 precursor
NM_201266.2	NP_957718.1	neuropilin-2 isoform 1 precursor
NM_201267.2	NP_957719.1	neuropilin-2 isoform 5 precursor
NM_201279.2	NP_958436.1	neuropilin-2 isoform 3 precursor

NRP2 Protein Structure

CUB

F5_F8_type_C

MAM

DUF3481

0
200
400
600
800
931 a.a.

Protein Preferred Names

Protein Names

neuropilin-2

neuropilin-2a(17)

NRP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	NRP2	O60462	Vegfc	Mus musculus	P97953-1	Solid Phase Assay	25752543
Cross	NRP2	O60462	Vegfc	Mus musculus	P97953-1	TSA	25752543

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73313	Neuropilin-2 Protein, Human (HEK293, Fc)	O60462 (Q23-Y855)	≥95%
HY-P73314	Neuropilin-2 Protein, Human (855a.a, HEK293, His)	O60462 (Q23-P859)	≥95%

Related Diseases

Diseases

Alias

Lymphangioma

Lymphatic Malformation	Lymphatic Malformations
Benign Lymphangioma	Congenital Lymphangioma
Lymphangiomas

Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Hereditary Lymphedema

Milroy Disease

Hereditary Lymphedema I

Lymphedema	Hereditary Lymphedema Type I
Congenital Primary Lymphedema	Lmph1
Milroy Disease	Nonne-Milroy Lymphedema
Pcl	Lymphedema Hereditary Type 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09580	NRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990782	Efzofitimod		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NRP2	RGD	RGD:621442
Bos taurus	NRP2	VGNC	VGNC:32267
Mus musculus	NRP2	MGD	MGI:1100492
Canis familiaris	NRP2	VGNC	VGNC:43975
Macaca mulatta	NRP2	VGNC	VGNC:75533
Felis catus	NRP2	VGNC	VGNC:68570
Others	NRP2	NCBI

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