Ntsr2 - neurotensin receptor 2 Gene

Mus musculus

Also known as NT2R; NTR2; NTRL; NT-R-2

Gene ID: 18217 | Gene type: protein coding

About Ntsr2

Chromosome 12: 16,703,383-16,710,228 forward strand.GRCm39:CM001005.3

This gene has 5 transcripts (splice variants), 79 orthologues, 14 paralogues and is associated with 4 phenotypes. Biased expression in genital fat pad adult (RPKM 7.4), cortex adult (RPKM 64.8) and 5 other tissues.

Summary

Enables G protein-coupled Neurotensin Receptor activity. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway and regulation of membrane potential. Located in membrane. Orthologous to human NTSR2 (Neurotensin Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ntsr2 Products(5)

mRNA	Protein	Name
NM_001361702.2	NP_001348631.1	neurotensin receptor type 2 isoform 2
NM_001361703.2	NP_001348632.1	neurotensin receptor type 2 isoform 3
NM_001412674.1	NP_001399603.1	neurotensin receptor type 2 isoform 4
NM_001412675.1	NP_001399604.1	neurotensin receptor type 2 isoform 5
NM_008747.3	NP_032773.2	neurotensin receptor type 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled neurotensin receptor activity	IDA IDA: Inferred from direct assay	8795617	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8795617	MGI
acts upstream of or within regulation of membrane potential	IDA IDA: Inferred from direct assay	8795617	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	8795617	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntsr2 Protein Structure

7tm_GPCRs

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

neurotensin receptor type 2

low affinity neurotensin receptor

low-affinity levocabastine-sensitive neurotensin receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS09641	NTSR2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS09642	Ntsr2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS09643	Ntsr2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntsr2	NCBI	NCBI:23620

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