2. Gene
  3. Kat2b - K(lysine) acetyltransferase 2B Gene

Kat2b - K(lysine) acetyltransferase 2B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pcaf; p/CAF; A930006P13Rik

Gene ID: 18519 | Gene type: protein coding

About Kat2b

Chromosome 17: 53,873,889-53,979,748 forward strand.GRCm39:CM001010.3

This gene has 7 transcripts (splice variants), 225 orthologues, 11 paralogues and is associated with 11 phenotypes. Ubiquitous expression in adrenal adult (RPKM 12.8), bladder adult (RPKM 11.9) and 28 other tissues.

Summary

Enables several functions, including N-acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and transcription coactivator activity. Involved in internal peptidyl-lysine acetylation and negative regulation of cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of gluconeogenesis; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including actomyosin; kinetochore; and sarcomere. Part of ATAC complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]

Kat2b Products(2)

mRNA Protein Name
NM_020005.4 NP_064389.2 histone acetyltransferase KAT2B isoform 1
NM_001190846.1 NP_001177775.1 histone acetyltransferase KAT2B isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21402781 MGI
enables acetyltransferase activity EXP
EXP: Inferred from Experiment
11250901 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16245309 MGI
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
19773423 MGI
enables histone H3K9 acetyltransferase activity IGI
IGI: Inferred from genetic interaction
24051374 MGI
enables histone acetyltransferase activity IDA
IDA: Inferred from direct assay
9742083 MGI
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
IDA: Inferred from direct assay
18250163 MGI
enables peptide-lysine-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
21084751 MGI
enables peptide-lysine-N-acetyltransferase activity IGI
IGI: Inferred from genetic interaction
21084751 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9742083 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19773423 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
15509593 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of gluconeogenesis IGI
IGI: Inferred from genetic interaction
24051374 MGI
acts upstream of or within internal peptidyl-lysine acetylation IGI
IGI: Inferred from genetic interaction
24051374 MGI
involved in internal peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
19773423 MGI
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
19773423 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15509593 MGI
acts upstream of or within positive regulation of gluconeogenesis IGI
IGI: Inferred from genetic interaction
24051374 MGI
involved in positive regulation of glycolytic process IDA
IDA: Inferred from direct assay
21084751 MGI
involved in positive regulation of lipid biosynthetic process IDA
IDA: Inferred from direct assay
21084751 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15601857 MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose IDA
IDA: Inferred from direct assay
21084751 MGI
Cellular Component GO Annotation Evidence Reference Source
located in A band IDA
IDA: Inferred from direct assay
18250163 MGI
part of ATAC complex IDA
IDA: Inferred from direct assay
19936620 MGI
located in I band IDA
IDA: Inferred from direct assay
18250163 MGI
located in actomyosin IDA
IDA: Inferred from direct assay
18250163 MGI
part of histone acetyltransferase complex IDA
IDA: Inferred from direct assay
9742083 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
14519686 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
21084751 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15509593 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kat2b Protein Structure

PCAF_N

PCAF_N: pfam06466 (55 - 306)

COG5076

COG5076: cl34891 (467 - 806)

Bromo_gcn5_like

Bromo_gcn5_like: cd05509 (707 - 806)

  • 0
  • 200
  • 400
  • 600
  • 813 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase KAT2B

histone acetylase PCAF

histone acetyltransferase PCAF

lysine acetyltransferase 2B

p300/CBP-associated factor

spermidine acetyltransferase KAT2B

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W015239 KAT8-IN-1 99.40% Unkown
HY-RS07077 KAT2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07078 Kat2b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07079 KAT2B Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kat2b NCBI NCBI:8850