2. Epigenetics
  3. Histone Acetyltransferase
  4. AUR1545

AUR1545 is a selective degrader of KAT2A and KAT2B. AUR1545 can be used in the cancer research, including studies on AML (Acute myeloid leukemia), SCLC (Small-cell carcinoma), and NEPC (Neuroendocrine Prostate Cancer).

For research use only. We do not sell to patients.

AUR1545 Chemical Structure

AUR1545 Chemical Structure

CAS No. : 3031593-79-7

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AUR1545 Related Antibodies

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Description

AUR1545 is a selective degrader of KAT2A and KAT2B. AUR1545 can be used in the cancer research, including studies on AML (Acute myeloid leukemia), SCLC (Small-cell carcinoma), and NEPC (Neuroendocrine Prostate Cancer)[1].

Cellular Effect
Cell Line Type Value Description References
LASCPC-01 DC50
0.16 nM
for KAT2B
for KAT2B
[1]
MOLM-13 DC50
0.11 nM
for KAT2A
for KAT2A
[1]
NCI-H1048 DC50
0.01 nM
for KAT2A
for KAT2A
[1]
MOLM-13 DC50
0.43 nM
for KAT2B
for KAT2B
[1]
NCI-H1048 DC50
0.04 nM
for KAT2B
for KAT2B
[1]
LASCPC-01 DC50
0.06 nM
for KAT2A
for KAT2A
[1]
Molecular Weight

828.80

Formula

C41H50BrN9O5
CAS No.
SMILES

O=C1C2=CC=C(N3CCN(CC3)CC4CCN(CC4)C(C5=CC=C([C@H]6C[C@H](CN(C6)C)NC7=C(C(N(N=C7)C)=O)Br)C=C5)=O)C=C2CN1C8C(NC(CC8)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AUR1545 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AUR15453031593-79-7AUR 1545AUR-1545Histone AcetyltransferaseHATsHATKAT2AKAT2BAMLAcute myeloid leukemiaSCLCSmall-cell carcinomaNEPCNeuroendocrine Prostate CancerInhibitorinhibitorinhibit

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HY-173158
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