DUSP9 - dual specificity phosphatase 9 Gene

Homo sapiens

Also known as MKP4; MKP-4

Gene ID: 1852 | Gene type: protein coding

About DUSP9

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,642,441-153,651,326 (from NCBI)

This gene has 3 transcripts (splice variants), 106 orthologues and 30 paralogues. Biased expression in placenta (RPKM 41.7) and kidney (RPKM 21.4).

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and Cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

DUSP9 Products(2)

mRNA	Protein	Name
NM_001318503.2	NP_001305432.1	dual specificity protein phosphatase 9
NM_001395.4	NP_001386.1	dual specificity protein phosphatase 9

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11988087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP9 Protein Structure

Rhodanese

DSPc

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 9

map kinase phosphatase 4

Related Diseases

Diseases

Alias

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04070	DUSP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DUSP9	VGNC	VGNC:28264
Felis catus	DUSP9	VGNC	VGNC:61671
Rattus norvegicus	DUSP9	RGD	RGD:1565535
Mus musculus	DUSP9	MGD	MGI:2387107
Canis familiaris	DUSP9	VGNC	VGNC:40137

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