2. Gene
  3. Pdgfa - platelet derived growth factor, alpha Gene

Pdgfa - platelet derived growth factor, alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PDGF-1

Gene ID: 18590 | Gene type: protein coding

About Pdgfa

Summary

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in digestive tract development and embryonic lung development. Acts upstream of or within several processes, including animal organ development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Located in extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfa Products(2)

mRNA Protein Name
NM_001363271.1 NP_001350200.1 platelet-derived growth factor subunit A isoform 2 precursor
NM_008808.4 NP_032834.1 platelet-derived growth factor subunit A isoform 1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
12176888 MGI
acts upstream of or within angiogenesis IDA
IDA: Inferred from direct assay
12101409 MGI
acts upstream of or within animal organ morphogenesis IGI
IGI: Inferred from genetic interaction
15361870 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
14522834 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
23938297 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within cell projection assembly IDA
IDA: Inferred from direct assay
12176888 MGI
acts upstream of or within digestive tract development IGI
IGI: Inferred from genetic interaction
23938297 MGI
involved in digestive tract development IMP
IMP: Inferred from mutant phenotype
10903171 MGI
involved in embryonic lung development IMP
IMP: Inferred from mutant phenotype
9374392 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
11803579 MGI
involved in lung alveolus development IMP
IMP: Inferred from mutant phenotype
9374392 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling IMP
IMP: Inferred from mutant phenotype
18559345 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
11940581 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
10331973 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
19734317 MGI
located in microvillus IDA
IDA: Inferred from direct assay
12101409 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet-derived growth factor subunit A

PDGF A-chain

PDGF subunit A

platelet-derived growth factor A-chain

platelet-derived growth factor alpha polypeptide

Recombinant Pdgfa Proteins

Cat. No. Product Name Accession Purity
HY-P7277 PDGF-AA Protein, Mouse P20033 (S87-T211) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D0889 Glycylglycine 99.90% Unkown
HY-D0889R Glycylglycine (Standard) / Unkown
HY-RS10250 PDGFA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W040074 Glycylglycine hydrochloride hydrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdgfa NCBI NCBI:5154
Canis familiaris Pdgfa NCBI NCBI:491597