PDGFA - platelet derived growth factor subunit A Gene

Homo sapiens

Also known as PDGF1; PDGF-A

Gene ID: 5154 | Gene type: protein coding

About PDGFA

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:497,258-520,700 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 8.8), placenta (RPKM 8.7) and 24 other tissues.

Summary

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF Receptor Tyrosine Kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

PDGFA Products(6)

mRNA	Protein	Name
NM_001395363.1	NP_001382292.1	platelet-derived growth factor subunit A isoform 3
NM_001395364.1	NP_001382293.1	platelet-derived growth factor subunit A isoform 4
NM_001395365.1	NP_001382294.1	platelet-derived growth factor subunit A isoform 5
NM_001395366.1	NP_001382295.1	platelet-derived growth factor subunit A isoform 2 preproprotein
NM_002607.6	NP_002598.4	platelet-derived growth factor subunit A isoform 1 preproprotein
NM_033023.5	NP_148983.1	platelet-derived growth factor subunit A isoform 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	8900172	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	12070119	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20534510	GOA
enables platelet-derived growth factor binding	IPI IPI: Inferred from physical interaction	7073684	GOA
enables platelet-derived growth factor receptor binding	IDA IDA: Inferred from direct assay	2439522	GOA
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	2536956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7679113	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	7073684	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	2836953	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative chemotaxis	IDA IDA: Inferred from direct assay	9409235	GOA
involved in negative regulation of phosphatidylinositol biosynthetic process	IDA IDA: Inferred from direct assay	2538439	GOA
involved in negative regulation of platelet activation	IDA IDA: Inferred from direct assay	2538439	GOA
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11788434	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	11788434	GOA
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16462734	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IDA IDA: Inferred from direct assay	19019919	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	12070119	GOA
NOT involved in regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	11788434	GOA
NOT involved in regulation of glomerular mesangial cell proliferation	IDA IDA: Inferred from direct assay	11788434	GOA
involved in regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	9409235	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	2538439	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	291037	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	3754619	GOA
part of platelet-derived growth factor complex	IPI IPI: Inferred from physical interaction	7679113	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFA Protein Structure

PDGF_N

PDGF

0
100
211 a.a.

Protein Preferred Names

Protein Names

platelet-derived growth factor subunit A

PDGF A-chain

Recombinant PDGFA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70598	PDGF-AA Protein, Human	P04085-1 (S87-T211)	≥95%
HY-P70825	PDGF-AA Protein, Human (His)	P04085-1 (S87-T211)	≥95%
HY-P74643	PDGF-AA Protein, Human (P.pastoris, His)	P04085-1 (S87-T211)	≥95%

Related Diseases

Diseases

Alias

Denys-Drash Syndrome

Drash Syndrome	DDS
Nephropathy, Wilms Tumor, And Genital Anomalies	Wilms Tumor And Pseudohermaphroditism
Wilms Tumor And Pseudo- Or True Hermaphroditism	Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor
Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor	Wilms Tumor-Dsd Syndrome
Wilms Tumor-Disorder Of Sex Development Syndrome

Ureteral Obstruction

Retinal Detachment

Retinal Detachments	Rhegmatogenous Retinal Detachment
Ruptured Retina With Detachment	Retinal Hole With Detachment

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Glioma

Diffuse Mesangial Sclerosis

Familial Mesangial Sclerosis	Mesangial Sclerosis, Diffuse
Dms	Diffuse Isolated Mesangial Sclerosis
Isolated Diffuse Mesangial Sclerosis	Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis

Familiar Ovarian Carcinoma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Ureter Small Cell Carcinoma

Ureteral Small Cell Carcinoma

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Bronchiectasis 2

Costello Syndrome

Faciocutaneoskeletal Syndrome	Fcs Syndrome
Congenital Myopathy With Excess Of Muscle Spindles	CSTLO
CMEMS	Fcss
Myopathy, Congenital, With Excess Of Muscle Spindles

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Mesothelioma, Malignant

Malignant Mesothelioma	Pleural Mesothelioma
MESOM	Mesothelioma, Somatic
Advanced Malignant Mesothelioma	Asbestos-Related Malignant Mesothelioma
Diffuse Malignant Mesothelioma	Malignant Tumor Of Mesothelium
Malignant Mesothelioma, Susceptibility To	Mesothelioma Diffuse Malignant
Mesothelioma	Malignant Pleural Mesothelioma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

High Grade Glioma

Malignant Glioma	Glial Cell Tumor
Glioma, Malignant	Malignant Neuroglial Tumor
Neuroglial Tumor	Glioma
Malignant Gliomas

Asbestos-Related Lung Carcinoma

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Gastrointestinal Stromal Tumor

GIST	Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Sarcoma	Gastrointestinal Stromal Tumor, Familial
Gant	Gastrointestinal Stromal Tumour
Stromal Tumor Of Gastrointestinal Tract	Stromal Tumour Of Gastrointestinal Tract
Gastrointestinal Stromal Neoplasm	Paraganglioma And Gastric Stromal Sarcoma
Plexosarcoma

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10250	PDGFA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDGFA	VGNC	VGNC:75926
Mus musculus	PDGFA	MGD	MGI:97527
Rattus norvegicus	PDGFA	RGD	RGD:3282
Canis familiaris	PDGFA	VGNC	VGNC:44368
Felis catus	PDGFA	VGNC	VGNC:68768
Bos taurus	PDGFA	VGNC	VGNC:32689
Others	PDGFA	NCBI

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