2. Gene
  3. Pikfyve - phosphoinositide kinase, FYVE type zinc finger containing Gene

Pikfyve - phosphoinositide kinase, FYVE type zinc finger containing Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p235; Pip5k; Pip5k3; Pipk5k3; PipkIII; 5230400C17Rik

Gene ID: 18711 | Gene type: protein coding

About Pikfyve

Chromosome 1: 65,225,842-65,317,854 forward strand.GRCm39:CM000994.3

This gene has 11 transcripts (splice variants), 205 orthologues, 13 paralogues and is associated with 46 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 3.4), CNS E18 (RPKM 3.3) and 28 other tissues.

Summary

Enables phosphotransferase activity, alcohol group as acceptor and zinc ion binding activity. Involved in several processes, including neutrophil chemotaxis; phosphatidylinositol metabolic process; and vesicle organization. Acts upstream of or within myelin assembly. Located in several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKfyve (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Apr 2022]

Pikfyve Products(2)

mRNA Protein Name
NM_001310624.1 NP_001297553.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform 1
NM_011086.2 NP_035216.2 1-phosphatidylinositol 3-phosphate 5-kinase isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IDA
IDA: Inferred from direct assay
10419465 MGI
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
IDA: Inferred from direct assay
9858586 MGI
enables 1-phosphatidylinositol-5-kinase activity IDA
IDA: Inferred from direct assay
10419465 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
14530284 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14530284 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11123925 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
9858586 MGI
Biological Process GO Annotation Evidence Reference Source
involved in 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process IDA
IDA: Inferred from direct assay
11123925 MGI
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9858586 MGI
involved in melanosome organization IMP
IMP: Inferred from mutant phenotype
29584722 MGI
acts upstream of or within myelin assembly IGI
IGI: Inferred from genetic interaction
22028665 MGI
involved in neutrophil chemotaxis IDA
IDA: Inferred from direct assay
28779020 MGI
NOT involved in neutrophil degranulation IDA
IDA: Inferred from direct assay
28779020 MGI
involved in peptidyl-serine autophosphorylation IDA
IDA: Inferred from direct assay
11123925 MGI
involved in phagosome maturation IDA
IDA: Inferred from direct assay
27623384 MGI
involved in phagosome-lysosome fusion IDA
IDA: Inferred from direct assay
28779020 MGI
involved in phosphatidylinositol 5-phosphate metabolic process IDA
IDA: Inferred from direct assay
11123925 MGI
involved in protein targeting to membrane IDA
IDA: Inferred from direct assay
14530284 MGI
involved in regulation of reactive oxygen species biosynthetic process IDA
IDA: Inferred from direct assay
28779020 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
11112776 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11112776 MGI
NOT located in insulin-responsive compartment IDA
IDA: Inferred from direct assay
11112776 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19056739 MGI
located in vesicle membrane IDA
IDA: Inferred from direct assay
9858586 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pikfyve Protein Structure

FYVE_PIKfyve_Fab1

FYVE_PIKfyve_Fab1: cd15725 (153 - 214)

DEP_PIKfyve

DEP_PIKfyve: cd04448 (356 - 437)

Fab1_TCP

Fab1_TCP: cd03334 (616 - 876)

PIPKc_PIKfyve

PIPKc_PIKfyve: cd17300 (1816 - 2082)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2097 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol 3-phosphate 5-kinase

FYVE finger-containing phosphoinositide kinase

PIPkin-III

PtdIns(4)P-5-kinase

phosphatidylinositol 3-phosphate 5-kinase type III

phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III

phosphatidylinositol-4-phosphate 5-kinase, type III

phosphoinositide kinase, FYVE finger containing

serine-protein kinase PIKFYVE

type III PIP kinase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-14644 Apilimod Inhibitor 99.80% Phase 2
HY-14644A Apilimod mesylate Inhibitor 99.83% Phase 2
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13228 YM-201636 Inhibitor 98.05% Unkown
HY-118630 Vacuolin-1 Inhibitor 98.93% Unkown
HY-15982 APY0201 Inhibitor 99.93% Unkown
HY-119624 MOMIPP Inhibitor 99.37% Unkown
HY-155994 PIK5-12d Degrader 99.90% Unkown
HY-151473 PIKfyve-IN-1 Inhibitor 99.64% Unkown
HY-160477 DC-SX029 Inhibitor 98.07% Unkown
HY-163133 PIKfyve-IN-3 99.55% Unkown
HY-161619 RMC-113 Inhibitor 99.54% Unkown
HY-154956 PIKfyve-IN-2 Inhibitor ≥98.0% Unkown
HY-163943 UNI418 Inhibitor 99.61% Unkown
HY-159625 WX8 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pikfyve NCBI NCBI:200576