2. PI3K/Akt/mTOR NF-κB
  3. NF-κB PIKfyve IKK
  4. DC-SX029

DC-SX029 is a potent SNX10 protein-protein interaction (PPI) inhibitor with oral activity with an estimated KD constant of ~0.935 μM by surface plasmon resonance (SPR). DC-SX029 blocks the SNX10-PIKfyve interaction, thereby decreased the TBK1/c-Rel signaling activation. DC-SX029 does not affect the protein level of SNX10. DC-SX029 has the potential for inflammatory bowel disease (IBD) research.

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DC-SX029 Chemical Structure

DC-SX029 Chemical Structure

CAS No. : 300713-88-6

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10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

DC-SX029 Related Antibodies

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IKK-α IKK-β IKK IKKε TBK1

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Description

DC-SX029 is a potent SNX10 protein-protein interaction (PPI) inhibitor with oral activity with an estimated KD constant of ~0.935 μM by surface plasmon resonance (SPR). DC-SX029 blocks the SNX10-PIKfyve interaction, thereby decreased the TBK1/c-Rel signaling activation. DC-SX029 does not affect the protein level of SNX10. DC-SX029 has the potential for inflammatory bowel disease (IBD) research[1][2].

In Vitro

DC-SX029 (50 μM, 6 h) inhibits PIKfyve-mediated TBK1/c-Rel signaling activation in BMDMs, reducing the inflammatory response[1].
DC-SX029 (10-50 μM, 2 h) significantly decreases LPS (HY-D1056)-induced nuclear localization of c-Rel and phosphorylation of TBK1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DC-SX029 Related Antibodies

RT-PCR[1]

Cell Line: BMDMs
Concentration: 50 μM
Incubation Time: 6 h
Result: Inhibited IL-12/23, IL-1β, IL-6 and TNF-α mRNA.

Western Blot Analysis[1]

Cell Line: BMDMs
Concentration: 10, 50 μM
Incubation Time: 2 h
Result: Reduced phosphorylation of TBK1.
In Vivo

DC-SX029 (1-6 mg/kg, orally, once a day for 10 days) can alleviate DSS-induced colitis in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse colitis model[1]
Dosage: 1, 2, 6 mg/kg; daily; 10 days
Administration: Oral
Result: Restored the body weight of mice, reduced DAI during the recovery period, reduced the shortening of colon length, reduced the production of pro-inflammatory cytokines, and had a significant alleviation effect on erosion, inflammatory cell infiltration and crypt loss.
Molecular Weight

398.35

Formula

C14H17F3N2O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(S(=O)(NCC(C(F)(F)F)CCC(O)=O)=O)C=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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DC-SX029 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC-SX029300713-88-6NF-κBPIKfyveIKKNuclear factor-κBNuclear factor-kappaBFYVE domain-containing phosphatidylinositol 3-phosphate 5-kinasePhosphatidylinositol 3-phosphate 5-kinaseFab1IκB kinaseI kappa B kinaseSNX10PPIsurface plasmon resonanceSPRSNX10-PIKfyveTBK1/c-Relinflammatory bowel diseaseIBDInhibitorinhibitorinhibit

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