Prkd1 - protein kinase D1 Gene

Mus musculus

Also known as PKD; PKD1; Pkcm; Prkcm; nPKC-D1; nPKC-mu

Gene ID: 18760 | Gene type: protein coding

About Prkd1

Chromosome 12: 50,388,014-50,695,881 reverse strand.GRCm39:CM001005.3

This gene has 1 transcript (splice variant), 208 orthologues, 2 paralogues and is associated with 12 phenotypes. Ubiquitous expression in genital fat pad adult (RPKM 3.1), subcutaneous fat pad adult (RPKM 2.4) and 26 other tissues.

Summary

Predicted to enable identical protein binding activity and protein kinase C activity. Involved in several processes, including positive regulation of osteoblast differentiation; positive regulation of protein import into nucleus; and regulation of keratinocyte proliferation. Acts upstream of or within regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including cell cortex; cell-cell junction; and trans-Golgi network. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human PRKD1 (protein kinase D1). [provided by Alliance of Genome Resources, Apr 2022]

Prkd1 Products(4)

mRNA	Protein	Name
NM_001382816.1	NP_001369745.1	serine/threonine-protein kinase D1 isoform 4
NM_001382815.1	NP_001369744.1	serine/threonine-protein kinase D1 isoform 3
NM_001382814.1	NP_001369743.1	serine/threonine-protein kinase D1 isoform 2
NM_008858.4	NP_032884.2	serine/threonine-protein kinase D1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17485491	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	28716882	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi vesicle transport	IMP IMP: Inferred from mutant phenotype	11239398	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	27184844	MGI
acts upstream of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	27782176	MGI
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	28716882	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19029091	MGI
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	27184844	MGI
involved in regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	20463010	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	23479225	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	10882525	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	10882525	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10882525	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11239398	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10882525	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10882525	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	11239398	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkd1 Protein Structure

C1_PKD1_rpt1

C1_PKD1_rpt2

PH_PKD

STKc_PKD

0
200
400
600
800
918 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase D1

protein kinase C mu type	protein kinase C, mu
protein kinase D

Prkd1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Prkd1	Q62101	ITGB3	Homo sapiens	P05106	Anti Bait CoIP	17485491

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11144	PRKD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11145	Prkd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11146	Prkd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkd1	NCBI	NCBI:5587

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