PRKD1 - protein kinase D1 Gene

Homo sapiens

Also known as PKD; PKCM; CHDED; PRKCM; PKC-MU

Gene ID: 5587 | Gene type: protein coding

About PRKD1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:29,576,479-29,927,847 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 3.2), prostate (RPKM 2.7) and 22 other tissues.

Summary

The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017]

PRKD1 Products(7)

mRNA	Protein	Name
NM_002742.3	NP_002733.2	serine/threonine-protein kinase D1 isoform 2
XR_943493.3
XM_047431589.1	XP_047287545.1	serine/threonine-protein kinase D1 isoform X1
NM_001330069.2	NP_001316998.1	serine/threonine-protein kinase D1 isoform 1
XM_047431590.1	XP_047287546.1	serine/threonine-protein kinase D1 isoform X3
NM_001348390.1	NP_001335319.1	serine/threonine-protein kinase D1 isoform 3
XM_011536965.3	XP_011535267.1	serine/threonine-protein kinase D1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12637538	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10831594	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	24623306	GOA
enables phosphatidylinositol 3-kinase activator activity	IDA IDA: Inferred from direct assay	22095288	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10831594	GOA
enables protein serine kinase activity	IGI IGI: Inferred from genetic interaction	20497126	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18440775	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	28428613	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	19211839	GOA
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	22095288	GOA
involved in cellular response to hydroperoxide	IMP IMP: Inferred from mutant phenotype	22095288	GOA
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	12505989	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	28428613	GOA
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	28428613	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12505989	GOA
involved in positive regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18332134	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22095288	GOA
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12505989	GOA
involved in positive regulation of endothelial cell chemotaxis	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18332134	GOA
involved in positive regulation of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	19211839	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	22095288	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	24623306	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18059339	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11239398	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	22095288	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19211839	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKD1 Protein Structure

C1_1

Pkinase

0
200
400
600
800
912 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase D1

nPKC-D1	nPKC-mu
protein kinase C mu type	protein kinase C, mu
protein kinase D

PRKD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKD1	Q15139	C1QBP	Homo sapiens	Q07021	Pull Down	10831594
Intra	PRKD1	Q15139	C1QBP	Homo sapiens	Q07021	Anti Bait CoIP	10831594
Intra	PRKD1	Q15139	PRKD3	Homo sapiens	O94806	Anti Tag CoIP	33961781
Intra	PRKD1	Q15139	MAPK13	Homo sapiens	O15264	Anti Tag CoIP	19135240
Intra	PRKD1	Q15139	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	PRKD1	Q15139	CDH1	Homo sapiens	P12830	Confocal	15695390
Intra	PRKD1	Q15139	CDH1	Homo sapiens	P12830	Anti Bait CoIP	15695390
Intra	PRKD1	Q15139	MT2A	Homo sapiens	P02795	Y2H	14550308
Intra	PRKD1	Q15139	MT2A	Homo sapiens	P02795	Beta Galactosidase	14550308
Intra	PRKD1	Q15139	MT2A	Homo sapiens	P02795	Confocal	14550308

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Heart Defects And Ectodermal Dysplasia

CHDED

Heart Defects, Congenital And Ectodermal Dysplasia

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Spermatogenic Failure 6

Globozoospermia	SPGF6
Round-Headed Spermatozoa	Acrosome Malformation Of Spermatozoa
Spermatogenic Failure 9	Spermatozoa, Round-Headed
Globozoospermia, Complete	Globozoospermia, Total
Mae Infertility Due To Round-Headed Spermatozoa	Male Infertility Due To Globozoospermia
Male Infertility Due To Round-Headed Spermatozoa	Round-Headed Sperm Syndrome
Spgf9	Teratozoospermia

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Caroli Disease

Caroli Disease Isolated	Congenital Polycystic Dilatation Of Intrahepatic Bile Ducts
Cystic Dilatation Of The Intrahepatic Biliary Tree	Caroli Syndrome
Carolis Disease

Congenital Nonspherocytic Hemolytic Anemia

Hereditary Nonspherocytic Hemolytic Anemia	Hereditary Non-Spherocytic Hemolytic Anemia
Anemia, Hemolytic, Congenital Nonspherocytic	Congenital Nonspherocytic Hemolytic Anaemia
Hereditary Nonspherocytic Hemolytic Anaemia	Hnsha

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Episodic Kinesigenic Dyskinesia 1

Paroxysmal Kinesigenic Choreoathetosis	Paroxysmal Kinesigenic Dyskinesia
Dystonia 10	Familial Paroxysmal Kinesigenic Dyskinesia
Episodic Kinesigenic Dyskinesia	EKD1
Pkc	Pkd
Dyt10	Familial Pkd
Paroxysmal Kinesigenic Choreathetosis	Familial Paroxysmal Dystonia
Dystonia, Familial Paroxysmal	Dyt-Prrt2
Dystonia, Type 10

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease	Arpkd
Polycystic Kidney Disease, Autosomal Recessive	Polycystic Kidney And Hepatic Disease 1
Pkhd1	PKD4
Polycystic Kidney Disease 4 With Or Without Hepatic Disease	Polycystic Kidney Disease, Infantile, Type I
Polycystic Kidney Disease, Infantile Type	Polycystic Kidney, Autosomal Recessive
Pkd3, Formerly	Polycystic Kidney Disease 4, With Or Without Hepatic Disease
Arpkd/Chf	Ar-Pkd
Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease	Infantile Polycystic Kidney Disease Type I
Pkd3	Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Head And Neck Cancer
Squamous Cell Carcinoma Of Lip	Squamous Cell Carcinoma, Head And Neck, Somatic
Carcinoma Of The Head And Neck	Squamous Cell Carcinomas Of Head And Neck
Scchn	Squamous Cell Carcinoma Of The Hypopharynx
Squamous Cell Carcinoma Of The Oropharynx	Squamous Cell Carcinoma Of Salivary Glands
Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses	Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses
Squamous Cell Carcinoma Of The Oral Cavity	Squamous Cell Carcinoma Of The Lip
Carcinoma, Squamous Cell Of Head And Neck	Lip Squamous Cell Carcinoma
Cancer, Head/Neck	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11144	PRKD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11145	Prkd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11146	Prkd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRKD1	VGNC	VGNC:53949
Mus musculus	PRKD1	MGD	MGI:99879
Felis catus	PRKD1	VGNC	VGNC:69065
Rattus norvegicus	PRKD1	RGD	RGD:620964
Canis familiaris	PRKD1	VGNC	VGNC:44986
Macaca mulatta	PRKD1	VGNC	VGNC:76414
Others	PRKD1	NCBI

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