2. Gene
  3. Plg - plasminogen Gene

Plg - plasminogen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pg

Gene ID: 18815 | Gene type: protein coding

About Plg

Summary

Enables kinase binding activity. Involved in trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including embryonic placenta development; muscle cell cellular homeostasis; and myoblast differentiation. Located in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is extrinsic component of plasma membrane. Is expressed in early conceptus; embryo; liver; and secondary oocyte. Human ortholog(s) of this gene implicated in COVID-19; conjunctivitis; myocardial infarction; plasminogen deficiency type I; and thrombophilia. Orthologous to several human genes including PLG (plasminogen). [provided by Alliance of Genome Resources, Apr 2022]

Plg Products(1)

mRNA Protein Name
NM_008877.3 NP_032903.3 plasminogen precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables kinase binding IPI
IPI: Inferred from physical interaction
24196407 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
12900459 MGI
acts upstream of or within mononuclear cell migration IMP
IMP: Inferred from mutant phenotype
17690254 MGI
acts upstream of or within muscle cell cellular homeostasis IMP
IMP: Inferred from mutant phenotype
11929773 MGI
acts upstream of or within myoblast differentiation IMP
IMP: Inferred from mutant phenotype
11929773 MGI
acts upstream of or within protein processing IDA
IDA: Inferred from direct assay
34380733 MGI
acts upstream of or within tissue regeneration IMP
IMP: Inferred from mutant phenotype
11929773 MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission IDA
IDA: Inferred from direct assay
15486301 MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
15486301 MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
15486301 MGI
acts upstream of or within trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
12900459 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
15486301 MGI
is active in Schaffer collateral - CA1 synapse IEP
IEP: Inferred from expression pattern
15486301 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
15486301 MGI
located in cell surface IDA
IDA: Inferred from direct assay
17690254 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15486301 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
15486301 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15486301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plasminogen

angiostatin

plasmin heavy chain A

plasmin light chain B

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103423 PAOPA Modulator 97.68% Unkown
HY-RS10704 PLG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plg NCBI NCBI:5340
Canis familiaris Plg NCBI NCBI:403602
Macaca fascicularis Plg NCBI NCBI:102145643
Rattus norvegicus Plg NCBI NCBI:85253
Macaca mulatta Plg NCBI NCBI:703891