2. Gene
  3. ECH1 - enoyl-CoA hydratase 1 Gene

ECH1 - enoyl-CoA hydratase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HPXEL

Gene ID: 1891 | Gene type: protein coding

About ECH1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,815,422-38,831,794 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 190 orthologues and 13 paralogues. Ubiquitous expression in liver (RPKM 139.0), fat (RPKM 120.0) and 25 other tissues.

Summary

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This Enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]

ECH1 Products(1)

mRNA Protein Name
NM_001398.3 NP_001389.2 delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15383276 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECH1 Protein Structure

ECH_1

ECH_1: Enoyl-CoA hydratase/isomerase (62 - 316)

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  • 328 a.a.
Protein Preferred Names Protein Names

delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

delta3,5-delta2,4-dienoyl-CoA isomerase

Recombinant ECH1 Proteins

Cat. No. Product Name Accession Purity
HY-P70059 ECH1 Protein, Human (His) Q13011 (T34-L328) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04136 ECH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04140 ECHS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ECH1 MGD MGI:1858208
Felis catus ECH1 VGNC VGNC:97408
Rattus norvegicus ECH1 RGD RGD:69353
Bos taurus ECH1 VGNC VGNC:28305
Canis familiaris ECH1 VGNC VGNC:40184
Others ECH1 NCBI