Prkdc - protein kinase, DNA activated, catalytic polypeptide Gene

Mus musculus

Also known as p460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; DNA-PKcs

Gene ID: 19090 | Gene type: protein coding

About Prkdc

Chromosome 16: 15,455,730-15,660,099 forward strand.GRCm39:CM001009.3

This gene has 2 transcripts (splice variants), 188 orthologues, 5 paralogues and is associated with 159 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 1.5), frontal lobe adult (RPKM 1.2) and 27 other tissues.

Summary

Enables DNA-dependent protein kinase activity; double-stranded DNA binding activity; and Enzyme binding activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of hematopoietic stem cell differentiation; and regulation of hemopoiesis. Acts upstream of or within several processes, including DNA metabolic process; ectopic germ cell programmed cell death; and immune system development. Located in nucleus. Is expressed in several structures, including central nervous system; neural retina; and thymus primordium. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Prkdc Products(1)

mRNA	Protein	Name
NM_011159.2	NP_035289.2	DNA-dependent protein kinase catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-dependent protein kinase activity	IDA IDA: Inferred from direct assay	23836881	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	20150414	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	20972425	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21266349	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell lineage commitment	IMP IMP: Inferred from mutant phenotype	8788039	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	9768755	MGI
acts upstream of or within T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	8788039	MGI
acts upstream of or within T cell receptor V(D)J recombination	IMP IMP: Inferred from mutant phenotype	9768755	MGI
acts upstream of or within V(D)J recombination	IGI IGI: Inferred from genetic interaction	23836881	MGI
acts upstream of or within brain development	IGI IGI: Inferred from genetic interaction	16687486	MGI
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	11751629	MGI
acts upstream of or within double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	23836881	MGI
acts upstream of or within ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	17145779	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	16687486	MGI
acts upstream of or within immature B cell differentiation	IMP IMP: Inferred from mutant phenotype	9768755	MGI
acts upstream of or within immunoglobulin V(D)J recombination	IMP IMP: Inferred from mutant phenotype	9768755	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	12604618	MGI
acts upstream of or within lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	8133891	MGI
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24158435	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17145779	MGI
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	32103174	MGI
involved in positive regulation of lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	32103174	MGI
involved in positive regulation of platelet formation	IMP IMP: Inferred from mutant phenotype	32103174	MGI
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	32103174	MGI
acts upstream of or within pro-B cell differentiation	IMP IMP: Inferred from mutant phenotype	9768755	MGI
acts upstream of or within protein destabilization	IDA IDA: Inferred from direct assay	15194694	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	24158435	MGI
involved in regulation of hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	32103174	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	9768755	MGI
acts upstream of or within response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	20150414	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	16687486	MGI
acts upstream of or within telomere maintenance	IMP IMP: Inferred from mutant phenotype	15010310	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12604618	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkdc Protein Structure

NUC194

DNAPKcs_CC5

FAT

TEL1

PIKKc_DNA-PK

FATC

0
700
1400
2100
2800
3500
4128 a.a.

Protein Preferred Names

Protein Names

DNA-dependent protein kinase catalytic subunit

DNA-PK catalytic subunit	doxorubicin nephropathy
severe combined immunodeficiency

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11151	PRKDC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11152	Prkdc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11153	Prkdc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkdc	NCBI	NCBI:5591

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