Mapk11 - mitogen-activated protein kinase 11 Gene

Mus musculus

Also known as P38b; Sapk2; p38-2; Prkm11; Sapk2b; p38beta; p38beta2

Gene ID: 19094 | Gene type: protein coding

About Mapk11

Chromosome 15: 89,026,689-89,033,831 reverse strand.GRCm39:CM001008.3

This gene has 4 transcripts (splice variants), 201 orthologues, 19 paralogues and is associated with 3 phenotypes. Broad expression in cortex adult (RPKM 22.5), CNS E14 (RPKM 2.2) and 2 other tissues.

Summary

Enables MAP kinase activity. Involved in MAPK cascade; bone development; and osteoblast differentiation. Acts upstream of or within negative regulation of cardiac muscle cell proliferation. Is active in cytosol. Is expressed in genitourinary system; lung; nervous system; and sensory organ. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Apr 2022]

Mapk11 Products(1)

mRNA	Protein	Name
NM_011161.5	NP_035291.4	mitogen-activated protein kinase 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase activity	IMP IMP: Inferred from mutant phenotype	20551513	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	16364914	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	20551513	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21768366	MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21768366	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	21768366	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IMP IMP: Inferred from mutant phenotype	20551513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 11

MAP kinase 11	MAP kinase p38 beta
MAPK 11	mitogen-activated protein kinase p38 beta
protein kinase, mitogen activated kinase, 11, p38beta

Mapk11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mapk11	Q9WUI1	Mapk14	Mus musculus	P47811	Y2H	15102471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08098	MAPK11 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08099	Mapk11 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08100	Mapk11 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk11	NCBI	NCBI:5600

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