MAPK11 - mitogen-activated protein kinase 11 Gene

Homo sapiens

Also known as P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2

Gene ID: 5600 | Gene type: protein coding

About MAPK11

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,263,713-50,270,380 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 19 paralogues. Ubiquitous expression in fat (RPKM 13.9), brain (RPKM 10.1) and 22 other tissues.

Summary

This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

MAPK11 Products(3)

mRNA	Protein	Name
XM_047441447.1	XP_047297403.1	mitogen-activated protein kinase 11 isoform X1
NR_110887.2
NM_002751.7	NP_002742.3	mitogen-activated protein kinase 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase activity	IDA IDA: Inferred from direct assay	8663524	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17254968	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	35857590	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	35857590	GOA
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	8663524	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in p38MAPK cascade	IDA IDA: Inferred from direct assay	10330143	GOA
NOT involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	23483889	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	8663524	GOA
involved in stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	35857590	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK11 Protein Structure

Pkinase

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 11

MAP kinase 11	MAP kinase p38 beta
mitogen-activated protein kinase p38 beta	mitogen-activated protein kinase p38-2
stress-activated protein kinase-2	stress-activated protein kinase-2b

MAPK11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	MAPK11	Q15759	MAPKAPK3	Homo sapiens	Q16644	Y2H	21988832
Intra	MAPK11	Q15759	MAPKAPK3	Homo sapiens	Q16644	TAP	23602568
Intra	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	MAPK11	Q15759	ZNHIT1	Homo sapiens	O43257	Pull Down	17380123
Intra	MAPK11	Q15759	ZNHIT1	Homo sapiens	O43257	Protein Kinase Assay	17380123
Intra	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	MAPK11	Q15759	TP53	Homo sapiens	P04637	Protein Kinase Assay	17254968
Intra	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Disorder Of Sexual Development

Disorder Of Sex Development	Sex Development Disorder
Sex Differentiation Disease	Dsd
Disorders Of Sex Development	Sex Differentiation Disorders

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Spinocerebellar Ataxia, X-Linked 5

SCAX5	X-Linked Spinocerebellar Ataxia 5
X-Linked Non Progressive Cerebellar Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08098	MAPK11 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08099	Mapk11 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08100	Mapk11 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAPK11	MGD	MGI:1338024
Felis catus	MAPK11	VGNC	VGNC:68165
Macaca mulatta	MAPK11	VGNC	VGNC:74642
Rattus norvegicus	MAPK11	RGD	RGD:1309340
Bos taurus	MAPK11	VGNC	VGNC:31214
Others	MAPK11	NCBI

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