Prnp - prion protein Gene

Mus musculus

Also known as PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP; prP27-30; prP33-35C

Gene ID: 19122 | Gene type: protein coding

About Prnp

Summary

Enables several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and cupric ion binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to membrane; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of apoptotic process; regulation of potassium ion transmembrane transport; and response to oxidative stress. Located in several cellular components, including Golgi apparatus; membrane raft; and terminal bouton. Colocalizes with dendrite. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; and fatal familial insomnia. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein). [provided by Alliance of Genome Resources, Apr 2022]

Prnp Products(2)

mRNA	Protein	Name
NM_001278256.1	NP_001265185.1	major prion protein precursor
NM_011170.3	NP_035300.1	major prion protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	19242475	MGI
enables aspartic-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	17573534	MGI
enables copper ion binding	IDA IDA: Inferred from direct assay	12500977	MGI
enables cupric ion binding	IMP IMP: Inferred from mutant phenotype	19381258	MGI
enables glycosaminoglycan binding	IDA IDA: Inferred from direct assay	17573534	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	19805070	MGI
enables metal ion binding	EXP EXP: Inferred from Experiment	11438695	MGI
enables metal ion binding	IDA IDA: Inferred from direct assay	11438695	MGI
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	29791485	MGI
enables molecular adaptor activity	IPI IPI: Inferred from physical interaction	28945221	MGI
enables molecular condensate scaffold activity	EXP EXP: Inferred from Experiment	34102212	MGI
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	34102212	MGI
enables protease binding	IPI IPI: Inferred from physical interaction	17573534	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11571277	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	19242475	MGI
enables signaling receptor activity	IMP IMP: Inferred from mutant phenotype	19242475	MGI
enables type 5 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	24012003	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of protein kinase activity	IGI IGI: Inferred from genetic interaction	23386614	MGI
NOT involved in amyloid precursor protein metabolic process	IGI IGI: Inferred from genetic interaction	20445063	MGI
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	24012003	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16254249	MGI
involved in learning or memory	IGI IGI: Inferred from genetic interaction	20445063	MGI
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	20145049	MGI
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20145049	MGI
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	20145049	MGI
involved in negative regulation of amyloid precursor protein catabolic process	IGI IGI: Inferred from genetic interaction	17573534	MGI
involved in negative regulation of amyloid-beta formation	IGI IGI: Inferred from genetic interaction	17573534	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	15753097	MGI
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	20145049	MGI
involved in negative regulation of dendritic spine maintenance	IGI IGI: Inferred from genetic interaction	22820466	MGI
involved in negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	20145049	MGI
involved in negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	20145049	MGI
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20145049	MGI
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	20145049	MGI
involved in neuron projection maintenance	IGI IGI: Inferred from genetic interaction	20445063	MGI
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	24012003	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	22820466	MGI
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23386614	MGI
involved in positive regulation of protein targeting to membrane	IGI IGI: Inferred from genetic interaction	22820466	MGI
involved in regulation of calcium ion import across plasma membrane	IGI IGI: Inferred from genetic interaction	22820466	MGI
involved in regulation of glutamate receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22820466	MGI
involved in regulation of peptidyl-tyrosine phosphorylation	IGI IGI: Inferred from genetic interaction	22820466	MGI
acts upstream of or within regulation of potassium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	24225951	MGI
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	10037495	MGI
involved in response to amyloid-beta	IGI IGI: Inferred from genetic interaction	22820466	MGI
acts upstream of or within response to oxidative stress	IDA IDA: Inferred from direct assay	12500977	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11756421	MGI
located in cell surface	IDA IDA: Inferred from direct assay	16254249	MGI
colocalizes with dendrite	IDA IDA: Inferred from direct assay	19242475	MGI
is active in dendrite	IDA IDA: Inferred from direct assay	24012003	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	11756421	MGI
located in membrane	IDA IDA: Inferred from direct assay	24225951	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	10037495	MGI
located in membrane raft	IMP IMP: Inferred from mutant phenotype	17573534	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9837873	MGI
located in terminal bouton	IDA IDA: Inferred from direct assay	15262264	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

major prion protein

Recombinant Prnp Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78023	PRNP/CD230 Protein, Mouse (HEK293, Fc)	P04925 (K23-S230)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11188	PRNP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prnp	NCBI	NCBI:5621

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