PRNP - prion protein Gene

Homo sapiens

Also known as CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C

Gene ID: 5621 | Gene type: protein coding

About PRNP

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,686,456-4,701,588 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and is associated with 13 phenotypes. Ubiquitous expression in brain (RPKM 148.7), ovary (RPKM 52.6) and 24 other tissues.

Summary

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

PRNP Products(12)

mRNA	Protein	Name
NM_000311.5	NP_000302.1	major prion protein preproprotein Prp precursor
NM_001080121.3	NP_001073590.1	major prion protein preproprotein Prp precursor
NM_001080122.3	NP_001073591.1	major prion protein preproprotein Prp precursor
NM_001080123.3	NP_001073592.1	major prion protein preproprotein Prp precursor
NM_001271561.3	NP_001258490.1	alternative prion protein isoform AltPrp
NM_183079.4	NP_898902.1	major prion protein preproprotein Prp precursor
NM_000311.5	NP_000302.1	major prion protein preproprotein Prp precursor
NM_001080121.3	NP_001073590.1	major prion protein preproprotein Prp precursor
NM_001080122.3	NP_001073591.1	major prion protein preproprotein Prp precursor
NM_001080123.3	NP_001073592.1	major prion protein preproprotein Prp precursor
NM_001271561.3	NP_001258490.1	alternative prion protein isoform AltPrp
NM_183079.4	NP_898902.1	major prion protein preproprotein Prp precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	24012003	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	22820466	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	11900542	GOA
enables cuprous ion binding	IMP IMP: Inferred from mutant phenotype	20564047	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16286452	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	16004966	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	30401430	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	30401430	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16286452	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23386614	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	16004966	GOA
NOT enables type 8 metabotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	24012003	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	24012003	GOA
acts upstream of or within cellular response to copper ion	IDA IDA: Inferred from direct assay	16254249	GOA
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	24012003	GOA
involved in positive regulation of glutamate receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24012003	GOA
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20564047	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	22820466	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	20564047	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	18419754	GOA
is active in dendrite	IDA IDA: Inferred from direct assay	24012003	GOA
located in inclusion body	IMP IMP: Inferred from mutant phenotype	20564047	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	16254249	GOA
located in membrane raft	IMP IMP: Inferred from mutant phenotype	23386614	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	21478263	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16254249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRNP Protein Structure

Prion_bPrPp

Prion

0
100
200
253 a.a.

Protein Preferred Names

Protein Names

major prion protein

alternative prion protein

CD230 antigen

Recombinant PRNP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74619	PRNP/CD230 Protein, Human (HEK293, Fc)	P04156/NP_000302.1 (K23-G229)	≥95%

Related Diseases

Diseases

Alias

Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease	CJD
Bovine Spongiform Encephalopathy	Vcjd
Inherited Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Familial
Creutzfeldt Jakob Disease	Creutzfeldt-Jacob Disease
Creutzfeldt Jacob Disease	Sporadic Creutzfeldt-Jakob Disease
Encephalopathy, Bovine Spongiform	Creutzfeldt-Jakob Disease, Variant, Resistance To
Creutzfeldt-Jakob Disease, Variant	Creutzfeldt Jacob Syndrome
Jakob-Creutzfeldt Disease	Subacute Spongiform Encephalopathy
Transmissible Virus Dementia	New Variant Of Cjd
Nv-Cjd	Variant Cjd
Variant Creutzfeldt-Jacob Disease	Sporadic Cjd
Inherited Cjd	Acquired Creutzfeldt-Jakob Disease
Variant Mcj	Encephalopathy Bovine Spongiform
Familial Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Syndrome
New Variant Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Sporadic
Acquired Cjd	Scjd - [Sporadic Creutzfeldt-Jakob Disease]
Idiopathic Creutzfeldt-Jakob Disease	Creutzfeld-Jakob Disease Nos
Vcjd - [Variant Creutzfeldt-Jakob Disease]

Fatal Familial Insomnia

Insomnia, Fatal Familial	FFI
Familial Fatal Insomnia	Insomnia Familial Fatal
Insomnia Fatal Familial	Insomnia, Fatal, Familial
Ffi - [Fatal Familial Insomnia]

Gerstmann-Straussler Disease

Gerstmann-Straussler-Scheinker Disease	Gerstmann-Straussler-Scheinker Syndrome
Prion Dementia	Cerebral Amyloid Angiopathy, Prnp-Related
GSD	Gss
Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns	Amyloidosis, Cerebral, With Spongiform Encephalopathy
Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type	Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type
Amyloidosis Cerebral With Spongiform Encephalopathy	Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System
Encephalopathy Subacute Spongiform Gerstmann-Straussler Type	Gssd
Gerstmann Straussler Scheinker Syndrome	Cerebral Amyloidosis With Spongiform Encephalopathy
Subacute Spongiform Encephalopathy Gerstmann-Straussler Type	Gluthathione Synthetase Deficiency
Gerstmann Straussler Syndrome

Huntington Disease-Like 1

HDL1	Huntington-Like Neurodegenerative Disorder 1
Hln1	Huntington'S Disease-Like 1
Early-Onset Prion Disease With Prominent Psychiatric Features	Huntington-Like Neurodegenerative Disorder, Autosomal Dominant
Prion Disease, Early-Onset, With Prominent Psychiatric Features	Autosomal Dominant Huntington-Like Neurodegenerative Disorder
Huntington Disease-Like, Type 1

Spongiform Encephalopathy With Neuropsychiatric Features

SENF

Kuru

Kuru, Susceptibility To	Kuru Encephalopathy
Kuru Encephalitis	Kuru Disease

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Inherited Human Prion Disease

Inherited Prion Disease	Familial Prion Disease
Genetic Human Prion Disease

Familial Alzheimer-Like Prion Disease

Prp Systemic Amyloidosis

Chronic Diarrhea With Hsan	Chronic Diarrhea With Hereditary Sensory And Autonomic Neuropathy
Prion Protein Systemic Amyloidosis

Scrapie

Chronic Wasting Disease

Wasting Disease, Chronic

Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related

Primary Progressive Aphasia	Grn-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions
Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions	Frontotemporal Dementia, Ubiquitin-Positive
Aphasia, Primary Progressive	Ppa
Ftld-Tdp, Grn-Related	Frontotemporal Dementia With Tdp43 Inclusions, Grn-Related
Ftldu	Ftdu
Dementia, Hereditary Dysphasic Disinhibition	Hddd
Primary Progressive Aphasia Syndrome	Mesulam Syndrome
Ubiquitin-Positive Frontotemporal Dementia	UP-FTD
Tau-Negative Frontotemporal Dementia Linked To Chromosome 17	Aphasia Primary Progressive
Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions, Susceptibility To	Aphasia, Primary Progressive, Susceptibility To
Frontotemporal Dementia

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Encephalopathy

Brain Diseases	Encephalopathies
Toxic Encephalopathy	Toxic Brain Fever
Toxic Brain Inflammation	Toxic Brain Stem Inflammation
Toxic Cerebral Fever	Toxic Cerebrospinal Fever
Toxic Cerebrospinal Inflammation	Encephalopathy Nec
Encephalopathy Nos	Encephalopathy Disease
Encephalopathy Syndrome

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Akinetic Mutism

Coma Vigilans

Aphasia

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Visual Cortex Disease

Visual Cortex Dysfunction	Visual Cortex Disorder
Visual Cortical Disorder	Disease Of Visual Cortex

Vascular Dementia

Dementia, Vascular	Multi Infarct Dementia
Multifocal Dementia	Dementia Vascular
Vascular Dementia, Susceptibility To	Dementia, Multi-Infarct
Multi-Infarct Dementia

Visual Pathway Disease

Disorder Of Visual Pathways

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Dentatorubral-Pallidoluysian Atrophy

DRPLA	Naito-Oyanagi Disease
Haw River Syndrome	Myoclonic Epilepsy With Choreoathetosis
Nod	Ataxia, Chorea, Seizures, And Dementia
Dentatorubropallidoluysian Atrophy	Hrs
Naito Oyanagi Disease	Dentatorubral Pallidoluysian Atrophy
Dentatorubro-Pallidoluysian Atrophy	Myoclonic Epilepsies, Progressive
Atrophy, Pallidoluysian, Dentatorubral

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Louping Ill

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Multiple System Atrophy 1

Multiple System Atrophy	Shy-Drager Syndrome
Msa	MSA1
Multiple System Atrophy 1, Susceptibility To	Sporadic Olivopontocerebellar Atrophy
Multisystem Atrophy	Msa1, Susceptibility To
Multiple System Atrophy, Susceptibility To	Opca
Progressive Autonomic Failure With Multiple System Atrophy	Sds

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy	Steele-Richardson-Olszewski Syndrome
Supranuclear Palsy, Progressive	Progressive Supranuclear Ophthalmoplegia
Psp	PSNP1
Familial Progressive Supranuclear Palsy	Richardson'S Syndrome
Psp Syndrome	Progressive Supranuclear Palsy 1
Supranuclear Palsy Progressive	Ophthalmoplegia, Supranuclear, Progressive
Steele-Richardson-Olszewksi Syndrome

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Agraphia

Ideomotor Apraxia

Apraxia, Ideomotor	Classic Apraxia
Ideomotor Dyspraxia	Limb-Kinetic Apraxia
Transcortical Apraxia

Spinocerebellar Ataxia 12

Spinocerebellar Ataxia Type 12	SCA12
Ataxia, Spinocerebellar, Type 12

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Gerstmann Syndrome

Aphasia-Angular Gyrus Syndrome	Developmental Gerstmann Syndrome
Gs	Gerstmann Badal Syndrome
Gerstmann Tetrad	Gerstmann'S Syndrome
Developmental Gerstmann'S Syndrome

Writing Disorder

Gait Apraxia

Cortical Blindness

Blindness, Cortical

Speech And Communication Disorders

Language Disorder	Communication Disorder
Language Disorders	Communication Disorders
Speech Language Disorder	Speech-Language Disorder
Communication Impairment	Speech And Language Disorder

Dystonia 25

DYT25	Dystonia-25
Dystonia, Type 25

Torsion Dystonia 2

Dystonia 2, Torsion, Autosomal Recessive

Alexia

Dyslexia	Dyslexia, Acquired
Acquired Dyslexia	Aphemesthaesia

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British	Fbd
Presenile Dementia With Spastic Ataxia	Familial British Dementia
Abri Amyloidosis	Cerebral Amyloid Angiopathy, British Type
Itm2b-Related Cerebral Amyloid Angiopathy 1	Familial Dementia, British Type
Cerebral Amyloid Angiopathy, Itm2b-Related 1	CAA-ITM2B1
Cerebral Amyloid Angiopathy British Type	Dementia, Familial, British

Mutism

Visual Agnosia

Primary Visual Agnosia

Pseudobulbar Palsy

Pseudobulbar Paralysis

Spinocerebellar Ataxia 45

SCA45

Spinocerebellar Ataxia Type 45

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Akinetopsia

Toxic Encephalopathy

Neurotoxicity	Neurotoxicity Syndromes
Neurotoxicity Syndrome	Encephalopathy, Toxic

Myopathy

Muscular Diseases

Myopathies

Cortical Deafness

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3

Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2

Choreatic Disease

Chorea

Hereditary Chorea

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Cerebellar Disease

Cerebellar Diseases	Cerebellar Dysfunction
Cerebellar Abnormality	Cerebellar Disorders

Movement Disease

Movement Disorders

Movement Disorder

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11188	PRNP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRNP	VGNC	VGNC:81156
Rattus norvegicus	PRNP	RGD	RGD:3410
Canis familiaris	PRNP	VGNC	VGNC:45004
Bos taurus	PRNP	VGNC	VGNC:33356
Macaca mulatta	PRNP	VGNC	VGNC:76424
Mus musculus	PRNP	MGD	MGI:97769
Others	PRNP	NCBI