Mtnr1b - melatonin receptor 1B Gene

Rattus norvegicus

Also known as Mt2; Mel1b-r

Gene ID: 192646 | Gene type: protein coding

About Mtnr1b

Primary_assembly 8: 12,638,219-12,652,737 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 106 orthologues, 50 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of cGMP-mediated signaling; negative regulation of transport; and regulation of transmission of nerve impulse. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Used to study acute pancreatitis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (Melatonin Receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Mtnr1b Products(1)

mRNA	Protein	Name
NM_001393841.1	NP_001380770.1	melatonin receptor type 1B precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in camera-type eye development	IEP IEP: Inferred from expression pattern	12890503	RGD
involved in negative regulation of cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	18363673	RGD
involved in negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	14675130	RGD
involved in negative regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	14962062	RGD
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18363673	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	14962062	RGD
involved in negative regulation of transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	15082174	RGD
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	10199853	RGD
involved in positive regulation of circadian rhythm	IDA IDA: Inferred from direct assay	12643943	RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep	IDA IDA: Inferred from direct assay	19429170	RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	22171046	RGD
involved in positive regulation of transmission of nerve impulse	IDA IDA: Inferred from direct assay	22171046	RGD
involved in regulation of neuronal action potential	IMP IMP: Inferred from mutant phenotype	21094224	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mtnr1b Protein Structure

7tm_GPCRs

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

melatonin receptor type 1B

mel-1B-R	mel1b melatonin receptor
mel1b receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08807	Mtnr1b Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08806	MTNR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08808	Mtnr1b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mtnr1b	NCBI	NCBI:4544

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