Mtnr1b - melatonin receptor 1B Gene

Rattus norvegicus

Also known as Mt2; Mel1b-r

Gene ID: 192646 | Gene type: protein coding

About Mtnr1b

Primary_assembly 8: 12,638,219-12,652,737 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 106 orthologues, 50 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of cGMP-mediated signaling; negative regulation of transport; and regulation of transmission of nerve impulse. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Used to study acute pancreatitis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (Melatonin Receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Mtnr1b Products(1)

mRNA	Protein	Name
NM_001393841.1	NP_001380770.1	melatonin receptor type 1B precursor

Mtnr1b Protein Structure

7tm_GPCRs

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

melatonin receptor type 1B

mel-1B-R	mel1b melatonin receptor
mel1b receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08807	Mtnr1b Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08806	MTNR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08808	Mtnr1b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mtnr1b	NCBI	NCBI:4544

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