MTNR1B - melatonin receptor 1B Gene

Homo sapiens

Also known as MT2; FGQTL2; MEL-1B-R

Gene ID: 4544 | Gene type: protein coding

About MTNR1B

Cytogenetic location: 11q14.3 Genomic coordinates (GRCh38): 11:92,969,651-92,984,960 (from NCBI)

This gene has 3 transcripts (splice variants), 106 orthologues, 33 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1B Products(3)

mRNA	Protein	Name
XM_017017777.2	XP_016873266.1	melatonin receptor type 1B isoform X1
NM_005959.5	NP_005950.1	melatonin receptor type 1B
XM_011542839.3	XP_011541141.1	melatonin receptor type 1B isoform X2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20859254	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	20668700	GOA
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	20668700	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTNR1B Protein Structure

7tm_1

0
100
200
300
362 a.a.

Protein Preferred Names

Protein Names

melatonin receptor type 1B

mel1b receptor

melatonin receptor MEL1B

MTNR1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MTNR1B	P49286	RGS20	Homo sapiens	O76081	Anti Tag CoIP	20859254
Intra	MTNR1B	P49286	MTNR1A	Homo sapiens	P48039	Anti Tag CoIP	20859254
Intra	MTNR1B	P49286	TRIP12	Homo sapiens	Q14669	Y2H	26514267
Intra	MTNR1B	P49286	HTR2C	Homo sapiens	P28335	Anti Tag CoIP	25770211
Intra	MTNR1B	P49286	HTR2C	Homo sapiens	P28335	IF	25770211

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Scoliosis

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Wolfram Syndrome 1

WFS1	Didmoad
Wfs	Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome
Wolfram Syndrome

Idiopathic Scoliosis

Scoliosis Idiopathic

Spermatogenic Failure 24

SPGF24

Spermatogenic Failure, Type 24

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diabetes Mellitus

Diabetes

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08807	Mtnr1b Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08806	MTNR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08808	Mtnr1b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MTNR1B	VGNC	VGNC:68351
Mus musculus	MTNR1B	MGD	MGI:2181726
Canis familiaris	MTNR1B	VGNC	VGNC:52269
Rattus norvegicus	MTNR1B	RGD	RGD:620798

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