Pla2g15 - phospholipase A2, group XV Gene

Mus musculus

Also known as ACS; LLPL; Lpla2; Lypla3

Gene ID: 192654 | Gene type: protein coding

About Pla2g15

Summary

Enables acylglycerol O-acyltransferase activity; calcium-independent Phospholipase A2 activity; and Phospholipase A1 activity. Involved in diacylglycerol biosynthetic process; phosphatidylcholine catabolic process; and phosphatidylethanolamine catabolic process. Acts upstream of or within ceramide metabolic process. Located in extracellular space and lysosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLA2G15 (Phospholipase A2 group XV). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g15 Products(2)

mRNA	Protein	Name
NM_001357319.1	NP_001344248.1	phospholipase A2 group XV isoform 2 precursor
NM_133792.3	NP_598553.1	phospholipase A2 group XV isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables O-acyltransferase activity	IDA IDA: Inferred from direct assay	16837646	MGI
enables acylglycerol O-acyltransferase activity	IDA IDA: Inferred from direct assay	17626977	MGI
enables calcium-independent phospholipase A2 activity	IDA IDA: Inferred from direct assay	11790796	MGI
NOT enables lysophospholipase activity	IDA IDA: Inferred from direct assay	11790796	MGI
enables phospholipase A1 activity	IDA IDA: Inferred from direct assay	16837646	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ceramide metabolic process	IDA IDA: Inferred from direct assay	11790796	MGI
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	16837646	MGI
involved in diacylglycerol biosynthetic process	IDA IDA: Inferred from direct assay	17626977	MGI
involved in glycerophospholipid metabolic process	IDA IDA: Inferred from direct assay	20410020	MGI
involved in phosphatidylcholine catabolic process	IDA IDA: Inferred from direct assay	16837646	MGI
involved in phosphatidylcholine catabolic process	IMP IMP: Inferred from mutant phenotype	16880524	MGI
involved in phosphatidylethanolamine catabolic process	IDA IDA: Inferred from direct assay	16837646	MGI
involved in phosphatidylethanolamine catabolic process	IMP IMP: Inferred from mutant phenotype	16880524	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	20410020	MGI
located in lysosome	IDA IDA: Inferred from direct assay	29514215	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipase A2 group XV

1-O-acylceramide synthase	LCAT-like lysophospholipase
group XV phospholipase A2	lysophospholipase 3
lysosomal phospholipase A and acyltransferase	lysosomal phospholipase A2

Recombinant Pla2g15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72293	Group XV phospholipase A2/Pla2g15, Mouse (His, myc)	Q8VEB4 (A34-P412)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10619	PLA2G15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pla2g15	NCBI	NCBI:23659

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