Ptx3 - pentraxin related gene Gene

Mus musculus

Also known as TSG-14

Gene ID: 19288 | Gene type: protein coding

About Ptx3

Summary

Enables (1->3)-beta-D-glucan binding activity. Acts upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Located in extracellular matrix. Is expressed in cochlea; cochlea epithelium; inner ear vestibular component; organ of Corti; and stria vascularis. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3). [provided by Alliance of Genome Resources, Apr 2022]

Ptx3 Products(1)

mRNA	Protein	Name
NM_008987.3	NP_033013.3	pentraxin-related protein PTX3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables (1->3)-beta-D-glucan binding	IMP IMP: Inferred from mutant phenotype	14726497	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17675295	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within extracellular matrix organization	IDA IDA: Inferred from direct assay	17675295	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	17675295	MGI
acts upstream of or within opsonization	IMP IMP: Inferred from mutant phenotype	14726497	MGI
acts upstream of or within ovarian cumulus expansion	IDA IDA: Inferred from direct assay	17675295	MGI
acts upstream of or within ovarian cumulus expansion	IMP IMP: Inferred from mutant phenotype	17675295	MGI
acts upstream of or within positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	14726497	MGI
acts upstream of or within positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	14726497	MGI
acts upstream of or within response to yeast	IMP IMP: Inferred from mutant phenotype	14726497	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	17675295	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pentraxin-related protein PTX3

pentaxin related	pentaxin-related protein PTX3
pentraxin 3	tumor necrosis factor-inducible gene 14 protein

Recombinant Ptx3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71246	PTX3 Protein, Mouse (HEK293, His)	P48759 (E18-S381)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11457	PTX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptx3	NCBI	NCBI:5806

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