PTX3 - pentraxin 3 Gene

Homo sapiens

Also known as TSG-14; TNFAIP5

Gene ID: 5806 | Gene type: protein coding

About PTX3

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:157,436,850-157,443,633 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 5 paralogues. Biased expression in bone marrow (RPKM 32.2), appendix (RPKM 24.8) and 6 other tissues.

Summary

This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

PTX3 Products(1)

mRNA	Protein	Name
NM_002852.4	NP_002843.2	pentraxin-related protein PTX3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables complement component C1q complex binding	IDA IDA: Inferred from direct assay	23544079	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20363749	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19050261	GOA
enables virion binding	IDA IDA: Inferred from direct assay	23544079	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in innate immune response	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation by host of viral exo-alpha-sialidase activity	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation by host of viral glycoprotein metabolic process	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation of exo-alpha-sialidase activity	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation of glycoprotein metabolic process	IDA IDA: Inferred from direct assay	23544079	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	23544079	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	23544079	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTX3 Protein Structure

Pentaxin

0
100
200
300
381 a.a.

Protein Preferred Names

Protein Names

pentraxin-related protein PTX3

TNF alpha-induced protein 5

Recombinant PTX3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73714	Pentraxin 3/TSG-14 Protein, Human (HEK293, His)	NP_002843.2 (E18-S381, with natural variants A48D)	≥95%

Related Diseases

Diseases

Alias

Takayasu Arteritis

Aortic Arch Syndrome	Pulseless Disease
Takayasu'S Arteritis	Idiopathic Aortitis
Young Female Arteritis	Aortic Arch Arteritis
Aortic Arches Defect	Aortic Arch Defects
Takayasu Disease	Aortic Arch Syndromes
Takayasu'S Disease	Ta
Obliterative Aortitis	Aortic Arch Giant-Cell Arteritis
Subclavian-Carotid Obstruction Syndrome	Idiopathic Medial Aortopathy And Arteriopathy
Takayasu Syndrome	Obliterative Brachiocephalic Arteritis Syndrome
Raeder-Harbitz Syndrome	Chronic Subclavian-Carotid Obstruction Syndrome
Giant-Cell Aortitis	Takayasu Aortitis
Nonspecific Aortoarteritis	Sclerosing Aortitis And Arteritis
Martorell 2 Syndrome	Young Female Aortic Arch Arteritis Syndrome

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Cryptococcosis

Cryptococcus Neoformans Infection	Torulosis
Busse-Buschke'S Disease	Cryptococcal Infection
European Cryptococcosis	Torula
Infection By Cryptococcus Neoformans	Cryptococcosis Infection
European Blastomycosis	European Blastomycotic Infection
European Blastomycoses Infection	Torula Histolytica Infection

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Acute Chest Syndrome

Acute Chest Syndrome In Sickle Cell Disease

Poems Syndrome

Crow-Fukase Syndrome	Osteosclerotic Myeloma
Polyneuropathy Organomegaly	Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, And Skin Changes Syndrome
Pep Syndrome	Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome
Takatsuki Syndrome

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Coronary Stenosis

Coronary Artery Stenosis

Appendicitis

Acute Appendicitis	Acute Appendicitis With Generalized Peritonitis
Acute Appendicitis Nos	Acute Appendicitis With Peritoneal Abscess
Appendiceal Inflammation	Appendicitis, Unqualified
Acute Appendix Inflammation	Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation
Acute Appendicitis With Free Peritonitis	Acute Appendicitis With Free Perforation To The Abdominal Cavity
Perforated Appendix With Generalised Peritonitis	Appendicitis With Perforation And Free Pus In The Peritoneal Cavity
Perforated Appendix With Localised Peritonitis	Acute Appendicitis With Contained Perforation To A Localised Abscess
Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation	Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation
Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess	Appendicitis With Abscess
Appendicitis With Peritoneal Abscess	Ruptured Appendix Nos
Acute Appendicitis With No Perforation Or Abscess And No Visible Pus	Acute Appendicitis With No Specification If Perforated Or Not
Acute Appendicitis With Phlegmone

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Erythema Nodosum

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Adenitis	Chronic Adenitis
Acute Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Leptospirosis

Fort Bragg Fever	Weil Disease
Leptospirosis Icterohaemorrhagica	Nanukayami Fever
Canicola Fever	Hemorrhagic Jaundice
Mud Fever	Stuttgart Disease
Swamp Fever	Rat Catcher'S Yellows
Spirochetal Jaundice	Weil'S Disease
Cane-Cutter Fever	Icterohemorrhagic Fever
Rice-Field Fever	Swineherd'S Disease
Weil Syndrome	Nanukayami
Canine Leptospirosis	Equine Infectious Anemia
Leptospirosis Canicola	Fever Due To Leptospira Autumnalis
Gikiyami	Leptospira Interrogans Autumnalis Infection
Leptospira Interrogans Canicola Infection	Leptospira Interrogans Hebdomadis Infection
Leptospira Interrogans Pomona Infection	Nanukayami Disease
Pretibial Fever	Seven-Day Fever
Eia - [Equine Infectious Anaemia]	Leptospira Interrogans Infection

Retinal Vein Occlusion

Occlusion, Of Retinal Vein

Orbital Granuloma

Invasive Aspergillosis

Aspergillosis Invasive

Chronic Salpingo-Oophoritis

Chronic Salpingitis And Oophoritis

Chronic Salpingitis/Oophoritis

Double Pterygium

Acute Salpingo-Oophoritis

Acute Salpingitis And Oophoritis

Temporal Arteritis

Polymyalgia Rheumatica	Giant Cell Arteritis
Cranial Arteritis	Horton Disease
Gca	Horton'S Disease
Rhizomelic Pseudopolyarthritis	Arteritis Cranialis
Arteritis Temporalis	Horton'S Arteritis
Horton'S Giant Cell Arteritis	Horton'S Temporal Arteritis
Horton'S Syndrome	Gca - [Giant Cell Arteritis]
Senile Arthritis	Polymyalgia Arteritica
Pmr - [Polymyalgia Rheumatica]	Forestier-Certonciny Syndrome
Rheumatic Polymyalgia	Polymyalgia

Trichosporonosis

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Central Nervous System Vasculitis

Vasculitis, Central Nervous System

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes	PPROM
Preterm Premature Rupture Of The Membranes, Susceptibility To	Pprom - [Preterm Premature Rupture Of Membranes]
Preterm Rupture Of Membranes

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diabetes Mellitus

Diabetes

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11457	PTX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTX3	MGD	MGI:104641
Macaca mulatta	PTX3	VGNC	VGNC:110346
Bos taurus	PTX3	VGNC	VGNC:33566
Canis familiaris	PTX3	VGNC	VGNC:45204
Rattus norvegicus	PTX3	RGD	RGD:1593476
Felis catus	PTX3	VGNC	VGNC:69185
Others	PTX3	NCBI