EFNA1 - ephrin A1 Gene

Homo sapiens

Also known as B61; EFL1; GMAN; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4

Gene ID: 1942 | Gene type: protein coding

About EFNA1

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,127,876-155,134,899 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 7 paralogues. Broad expression in placenta (RPKM 65.2), lung (RPKM 54.9) and 22 other tissues.

Summary

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EphA2, EphA4, EphA5, EphA6, and EphA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

EFNA1 Products(2)

mRNA	Protein	Name
NM_004428.3	NP_004419.2	ephrin-A1 isoform a precursor
NM_182685.2	NP_872626.1	ephrin-A1 isoform b precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	11519828	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19525919	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IDA IDA: Inferred from direct assay	10655584	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	10655584	GOA
involved in ephrin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in negative regulation of proteolysis involved in protein catabolic process	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in positive regulation of amyloid-beta formation	IDA IDA: Inferred from direct assay	24217950	GOA
involved in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10655584	GOA
involved in positive regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in positive regulation of protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in protein stabilization	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	10655584	GOA
involved in substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	10655584	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFNA1 Protein Structure

Ephrin

0
100
205 a.a.

Protein Preferred Names

Protein Names

ephrin-A1

TNF alpha-induced protein 4

EFNA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EFNA1	P20827	EPHA2	Homo sapiens	P29317	X-Ray Diffraction	19525919
Intra	EFNA1	P20827	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	19573808
Intra	EFNA1	P20827	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	22244754

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EFNA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70164	Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His)	AAH32698.1/NP_004419.2 (D19-S182)	≥95%
HY-P72662	Ephrin-A1/EFNA1 Protein, Human (HEK293, Fc)	P20827-1 (D19-S182)	≥95%

Related Diseases

Diseases

Alias

Cortical Senile Cataract

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04192	EFNA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EFNA1	VGNC	VGNC:72167
Canis familiaris	EFNA1	VGNC	VGNC:40226
Felis catus	EFNA1	VGNC	VGNC:61748
Bos taurus	EFNA1	VGNC	VGNC:28355
Rattus norvegicus	EFNA1	RGD	RGD:620388
Mus musculus	EFNA1	MGD	MGI:103236
Others	EFNA1	NCBI

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