Rbp4 - retinol binding protein 4, plasma Gene

Mus musculus

Also known as Rbp-4

Gene ID: 19662 | Gene type: protein coding

About Rbp4

Summary

Enables retinol binding activity. Involved in several processes, including animal organ development; gluconeogenesis; and negative regulation of cardiac muscle cell proliferation. Acts upstream of or within several processes, including detection of LIGHT stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Rbp4 Products(2)

mRNA	Protein	Name
NM_001159487.1	NP_001152959.1	retinol-binding protein 4 isoform 1
NM_011255.3	NP_035385.1	retinol-binding protein 4 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23105095	MGI
enables retinol binding	IDA IDA: Inferred from direct assay	12484775	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	12663486	MGI
acts upstream of or within detection of light stimulus involved in visual perception	IMP IMP: Inferred from mutant phenotype	12484775	MGI
acts upstream of or within embryo development	IGI IGI: Inferred from genetic interaction	18093970	MGI
involved in embryonic organ morphogenesis	IMP IMP: Inferred from mutant phenotype	15994349	MGI
involved in embryonic retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	10469643	MGI
involved in embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	15994349	MGI
involved in eye development	IMP IMP: Inferred from mutant phenotype	15994349	MGI
involved in female genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	15994349	MGI
involved in gluconeogenesis	IMP IMP: Inferred from mutant phenotype	16034410	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	15994349	MGI
involved in heart trabecula formation	IMP IMP: Inferred from mutant phenotype	12663486	MGI
involved in lung development	IMP IMP: Inferred from mutant phenotype	15994349	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	16586441	MGI
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	12663486	MGI
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	10944490	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	16034410	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	11562477	MGI
acts upstream of or within retinal metabolic process	IMP IMP: Inferred from mutant phenotype	11562477	MGI
acts upstream of or within retinol metabolic process	IGI IGI: Inferred from genetic interaction	18093970	MGI
acts upstream of or within retinol transport	IGI IGI: Inferred from genetic interaction	23105095	MGI
acts upstream of or within retinol transport	IMP IMP: Inferred from mutant phenotype	11562477	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	16586441	MGI
involved in urinary bladder development	IMP IMP: Inferred from mutant phenotype	15994349	MGI
involved in uterus development	IMP IMP: Inferred from mutant phenotype	15994349	MGI
involved in vagina development	IMP IMP: Inferred from mutant phenotype	15994349	MGI
acts upstream of or within vitamin A import into cell	IMP IMP: Inferred from mutant phenotype	12484775	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	16034410	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

retinol-binding protein 4

PRBP	RBP
plasma retinol-binding protein	retinol binding protein 4, cellular

Recombinant Rbp4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74599	RBP4 Protein, Mouse (HEK293, His)	Q00724 (E19-L201)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107633	A 1120		99.42%	Unkown
HY-143793	RBP4 inhibitor 1		99.74%	Unkown
HY-147366	RBP4 ligand-1	Inhibitor	/	Unkown
HY-RS11769	RBP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rbp4	NCBI	NCBI:5950
Canis familiaris	Rbp4	NCBI	NCBI:477775
Macaca fascicularis	Rbp4	NCBI	NCBI:102136826
Rattus norvegicus	Rbp4	NCBI	NCBI:25703

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