WDR90 - WD repeat domain 90 Gene

Homo sapiens

Also known as POC16; C16orf15; C16orf16; C16orf17; C16orf18; C16orf19

Gene ID: 197335 | Gene type: protein coding

About WDR90

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:648,979-667,830 (from NCBI)

This gene has 25 transcripts (splice variants), 169 orthologues and 9 paralogues. Broad expression in testis (RPKM 12.0), bone marrow (RPKM 4.3) and 23 other tissues.

Summary

Involved in cilium assembly. Located in centriole. [provided by Alliance of Genome Resources, Apr 2022]

WDR90 Products(1)

mRNA	Protein	Name
NM_145294.5	NP_660337.3	WD repeat-containing protein 90

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	28781053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	28781053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR90 Protein Structure

DUF667

WD40

Nup160

WD40

0
300
600
900
1200
1500
1748 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 90

WDR90 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR90	Q96KV7	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Loeys-Dietz Syndrome 2

LDS2	Aat3
Marfan Syndrome Type 2	Aortic Aneurysm, Familial Thoracic 3
Marfan Syndrome Type Ii	Loeys-Dietz Syndrome Type 2
Mfs2	Marfan Syndrome, Type Ii, Formerly
Familial Throacic Aortic Aneurysm 3	Familial Aortic Aneurysm Thoracic Type 3
Taad2	Thoracic Aortic Aneurysms And Dissection 2
Aneurysm, Aortic, Thoracic, Familial, Type 3	Loeys-Dietz Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15802	WDR90 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WDR90	VGNC	VGNC:48397
Rattus norvegicus	WDR90	RGD	RGD:7520481
Felis catus	WDR90	VGNC	VGNC:107831
Mus musculus	WDR90	MGD	MGI:1921267
Bos taurus	WDR90	VGNC	VGNC:36926

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