EIF4EBP2 - eukaryotic translation initiation factor 4E binding protein 2 Gene

Homo sapiens

Also known as 4EBP2; PHASII

Gene ID: 1979 | Gene type: protein coding

About EIF4EBP2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,404,145-70,428,618 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 50.2), kidney (RPKM 34.8) and 25 other tissues.

Summary

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, Insulin and Other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral Infection. [provided by RefSeq, Oct 2008]

EIF4EBP2 Products(1)

mRNA	Protein	Name
NM_004096.5	NP_004087.1	eukaryotic translation initiation factor 4E-binding protein 2

EIF4EBP2 Protein Structure

eIF_4EBP

0
100
120 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4E-binding protein 2

4E-BP2

EIF4EBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF4EBP2	Q13542	EIF4E	Homo sapiens	P06730	NMR	24207126
Intra	EIF4EBP2	Q13542	EIF4E	Homo sapiens	P06730	Y2H Prey Pooling	25416956
Intra	EIF4EBP2	Q13542	EIF4E	Homo sapiens	P06730	ITC	24207126
Intra	EIF4EBP2	Q13542	EIF4E	Homo sapiens	P06730	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF4EBP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70416	EIF4EBP2 Protein, Human (His)	Q13542 (M1-I120)	≥95%

Related Diseases

Diseases

Alias

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04278	EIF4EBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EIF4EBP2	VGNC	VGNC:28413
Canis familiaris	EIF4EBP2	VGNC	VGNC:40287
Mus musculus	EIF4EBP2	MGD	MGI:109198
Rattus norvegicus	EIF4EBP2	RGD	RGD:1310824
Macaca mulatta	EIF4EBP2	VGNC	VGNC:106043
Others	EIF4EBP2	NCBI

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