GKN2 - gastrokine 2 Gene

Homo sapiens

Also known as GDDR; TFIZ1; PRO813; BRICD1B; VLTI465

Gene ID: 200504 | Gene type: protein coding

About GKN2

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,945,232-68,952,893 (from NCBI)

This gene has 2 transcripts (splice variants), 126 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 1463.9).

Summary

The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric Cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]

GKN2 Products(1)

mRNA	Protein	Name
NM_182536.3	NP_872342.2	gastrokine-2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GKN2 Protein Structure

BRICHOS

0
100
184 a.a.

Protein Preferred Names

Protein Names

gastrokine-2

BRICHOS domain containing 1B

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05462	GKN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GKN2	VGNC	VGNC:41247
Bos taurus	GKN2	VGNC	VGNC:29389
Mus musculus	GKN2	MGD	MGI:1913534
Macaca mulatta	GKN2	VGNC	VGNC:72995
Rattus norvegicus	GKN2	RGD	RGD:1311934
Felis catus	GKN2	VGNC	VGNC:62571

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