2. Gene
  3. MUC20 - mucin 20, cell surface associated Gene

MUC20 - mucin 20, cell surface associated Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MUC-20

Gene ID: 200958 | Gene type: protein coding

About MUC20

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,720,978-195,733,551 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele and 73 orthologues. Broad expression in gall bladder (RPKM 28.1), colon (RPKM 25.9) and 17 other tissues.

Summary

This gene encodes a member of the Mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a Mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]

MUC20 Products(4)

mRNA Protein Name
NM_001282506.2 NP_001269435.1 mucin-20 isoform a precursor
NM_001291833.1 NP_001278762.1 mucin-20 isoform c precursor
NM_020790.1 NP_065841.1 mucin-20 isoform d precursor
NM_152673.3 NP_689886.3 mucin-20 isoform b precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15314156 GOA
Cellular Component GO Annotation Evidence Reference Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
15314156 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-20

transmembrane mucin MUC20S

Related Diseases

Diseases Alias
Childhood Hepatocellular Carcinoma

Pediatric Hepatocellular Carcinoma

Childhood Carcinoma Of Liver Cell

Childhood Hepatoma

Childhood Liver Cell Carcinoma

Pediatric Carcinoma Of Liver Cell

Pediatric Hepatoma

Pediatric Liver Cell Carcinoma

Childhood-Onset Hcc

Childhood-Onset Hepatocellular Carcinoma

Pediatric Hcc

Childhood Liver Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08839 MUC20 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MUC20 VGNC VGNC:43500
Rattus norvegicus MUC20 RGD RGD:1304865
Macaca mulatta MUC20 VGNC VGNC:75008
Felis catus MUC20 VGNC VGNC:108367
Mus musculus MUC20 MGD MGI:2385039
Bos taurus MUC20 VGNC VGNC:54458