RAB12 - RAB12, member RAS oncogene family Gene

Homo sapiens

Gene ID: 201475 | Gene type: protein coding

About RAB12

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:8,609,437-8,639,383 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 68 paralogues. Ubiquitous expression in heart (RPKM 8.8), fat (RPKM 6.8) and 25 other tissues.

Summary

Enables GDP binding activity. Predicted to be involved in several processes, including cellular response to Insulin stimulus; endosome to lysosome transport; and secretion by cell. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in lysosome; phagocytic vesicle; and recycling endosome membrane. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAB12 Products(1)

mRNA	Protein	Name
NM_001025300.3	NP_001020471.3	ras-related protein Rab-12

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26824392	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB12 Protein Structure

Ras

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-12

putative Ras-related protein Rab-12

RAB12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB12	Q6IQ22	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	26824392

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Newfoundland Rod-Cone Dystrophy

Newfoundland Cone-Rod Dystrophy	NFRCD
Rod-Cone Dystrophy Newfoundland

Periampullary Adenocarcinoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11521	RAB12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAB12	MGD	MGI:894284
Rattus norvegicus	RAB12	RGD	RGD:3527
Felis catus	RAB12	VGNC	VGNC:80472
Bos taurus	RAB12	VGNC	VGNC:33620
Macaca mulatta	RAB12	VGNC	VGNC:104237
Canis familiaris	RAB12	VGNC	VGNC:103700

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