RAB12 - RAB12, member RAS oncogene family Gene

Homo sapiens

Gene ID: 201475 | Gene type: protein coding

About RAB12

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:8,609,437-8,639,383 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 68 paralogues. Ubiquitous expression in heart (RPKM 8.8), fat (RPKM 6.8) and 25 other tissues.

Summary

Enables GDP binding activity. Predicted to be involved in several processes, including cellular response to Insulin stimulus; endosome to lysosome transport; and secretion by cell. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in lysosome; phagocytic vesicle; and recycling endosome membrane. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAB12 Products(1)

mRNA	Protein	Name
NM_001025300.3	NP_001020471.3	ras-related protein Rab-12

RAB12 Protein Structure

Ras

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-12

putative Ras-related protein Rab-12

Related Diseases

Diseases

Alias

Newfoundland Rod-Cone Dystrophy

Newfoundland Cone-Rod Dystrophy	NFRCD
Rod-Cone Dystrophy Newfoundland

Periampullary Adenocarcinoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11521	RAB12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAB12	MGD	MGI:894284
Rattus norvegicus	RAB12	RGD	RGD:3527
Felis catus	RAB12	VGNC	VGNC:80472
Bos taurus	RAB12	VGNC	VGNC:33620
Macaca mulatta	RAB12	VGNC	VGNC:104237
Canis familiaris	RAB12	VGNC	VGNC:103700

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