2. Gene
  3. EPHA1 - EPH receptor A1 Gene

EPHA1 - EPH receptor A1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EPH; EPHT; EPHT1

Gene ID: 2041 | Gene type: protein coding

About EPHA1

Cytogenetic location: 7q34-q35 Genomic coordinates (GRCh38): 7:143,391,129-143,408,856 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 124 orthologues and 53 paralogues. Ubiquitous expression in esophagus (RPKM 21.6), skin (RPKM 11.4) and 25 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human Cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

EPHA1 Products(1)

mRNA Protein Name
NM_005232.5 NP_005223.4 ephrin type-A receptor 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables fibronectin binding IDA
IDA: Inferred from direct assay
18308734 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
12775584 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19118217 GOA
enables transmembrane-ephrin receptor activity IDA
IDA: Inferred from direct assay
19118217 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
19118217 GOA
involved in cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
19118217 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
19118217 GOA
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
19118217 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
12775584 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
20043122 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20043122 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20043122 GOA
involved in positive regulation of cell-matrix adhesion IDA
IDA: Inferred from direct assay
19118217 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
19118217 GOA
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
19118217 GOA
involved in substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
19118217 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
16862074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA1 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (27 - 204)

fn3

fn3: Fibronectin type III domain (334 - 428)

fn3

fn3: Fibronectin type III domain (455 - 528)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (550 - 621)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (626 - 880)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (914 - 975)

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  • 976 a.a.
Protein Preferred Names Protein Names

ephrin type-A receptor 1

eph tyrosine kinase 1

Recombinant EPHA1 Proteins

Cat. No. Product Name Accession Purity
HY-P70321 EphA1 Protein, Human (HEK293, His) AAI30292.1 (K26-E547) ≥95%
HY-P75242 EphA1 Protein, Human (HEK293, hFc) EAL23789.1 (K26-E547) ≥95%

Related Diseases

Diseases Alias
Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia

CFNS

Cfnd

Craniofrontonasal Dysostosis

Craniofrontonasal Dystosis

Dysplasia, Craniofrontonasal
Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Retinitis Pigmentosa 18

RP18

Retinitis Pigmentosa-18

Retinitis Pigmentosa, Type 18
Alzheimer Disease 4

AD4

Alzheimer Disease-4

Alzheimer'S Disease 4

Alzheimer Disease, Familial, 4

Alzheimer Disease, Familial4

Alzheimer'S Disease 4, Early Onset

Alzheimer Disease, Type 4
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Leukodystrophy, Hypomyelinating, 5

Hypomyelination And Congenital Cataract

HLD5

Hypomyelination-Congenital Cataract Syndrome

Hypomyelinating Leukodystrophy 5

Hcc

Hypomyelination And Congenital Cataract: Hcc

Hypomyelination - Congenital Cataract

Hypomyelination With Congenital Cataract
Saethre-Chotzen Syndrome

SCS

Acs3

Acs Iii

Chotzen Syndrome

Acrocephaly, Skull Asymmetry, And Mild Syndactyly

Acrocephalosyndactyly Type 3

Acrocephalosyndactyly, Type Iii

Acrocephalosyndactyly Type Iii

Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies

Auralcephalosyndactyly

Acs 3

Acrocephalo-Syndactyly, Type 3

Blepharophimosis,Epicanthus Inversus, And Ptosis 3

Aural Cephalosyndactyly

Kurczynski-Casperson Syndrome

Acrocephalosyndactyly Iii

Dysostosis Craniofacialis With Hypertelorism

Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies

Sakati Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W074890 Palmitoylglycine Modulator 99.74% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-RS04424 EPHA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EPHA1 RGD RGD:1304680
Bos taurus EPHA1 VGNC VGNC:28532
Canis familiaris EPHA1 VGNC VGNC:40404
Felis catus EPHA1 VGNC VGNC:61901
Macaca mulatta EPHA1 VGNC VGNC:108400
Mus musculus EPHA1 MGD MGI:107381
Macaca fascicularis EPHA1 NCBI NCBI:102123244
Others EPHA1 NCBI