2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation
  3. Calcium Channel NO Synthase
  4. Palmitoylglycine

Palmitoylglycine  (Synonyms: N-palmitoyl glycine)

Cat. No.: HY-W074890 Purity: 99.74%
SDS COA Handling Instructions Technical Support

Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA.

For research use only. We do not sell to patients.

Palmitoylglycine Chemical Structure

Palmitoylglycine Chemical Structure

CAS No. : 2441-41-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of Palmitoylglycine:

Palmitoylglycine Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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nNOS iNOS eNOS

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].

In Vitro

Palmitoylglycine induces transient calcium influx in native adult DRG cells and in a DRG-like cell line[3].
Palmitoylglycine contributes to the production of nitric oxide (NO) through calcium-sensitive nitric oxide synthase (NOS) enzymes present in F-11 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Palmitoylglycine Related Antibodies
In Vivo

Palmitoylglycine potently inhibits heat-evoked firing of nociceptive neurons in rat dorsal horn[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

313.48

Formula

C18H35NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CNC(CCCCCCCCCCCCCCC)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (15.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1900 mL 15.9500 mL 31.9000 mL
5 mM 0.6380 mL 3.1900 mL 6.3800 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

SDS (393 KB)

COA (238 KB) HNMR (268 KB) RP-HPLC (216 KB) MS (79 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1900 mL 15.9500 mL 31.9000 mL 79.7499 mL
5 mM 0.6380 mL 3.1900 mL 6.3800 mL 15.9500 mL
10 mM 0.3190 mL 1.5950 mL 3.1900 mL 7.9750 mL
15 mM 0.2127 mL 1.0633 mL 2.1267 mL 5.3167 mL
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Palmitoylglycine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmitoylglycine2441-41-0N-palmitoyl glycineCalcium ChannelNO SynthaseCa2+ channelsCa channelsNitric oxide synthasesNOSendogenous lipidcalcium influx modulatornitric oxideNO productionsensory neuronsInhibitorinhibitorinhibit

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