Slc1a2 - solute carrier family 1 (glial high affinity glutamate transporter), member 2 Gene

Mus musculus

Also known as GLT1; Eaat2; GLT-1; MGLT1; 1700091C19Rik; 2900019G14Rik

Gene ID: 20511 | Gene type: protein coding

About Slc1a2

Chromosome 2: 102,489,004-102,621,129 forward strand.GRCm39:CM000995.3

This gene has 12 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 10 phenotypes. Biased expression in cortex adult (RPKM 172.), frontal lobe adult (RPKM 137.5) and 2 other tissues.

Summary

Enables cysteine transmembrane transporter activity and high-affinity glutamate transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; positive regulation of glucose import; and visual behavior. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a2 Products(4)

mRNA	Protein	Name
NM_001361018.1	NP_001347947.1	excitatory amino acid transporter 2 isoform 4
NM_001077515.2	NP_001070983.1	excitatory amino acid transporter 2 isoform 2
NM_001077514.4	NP_001070982.1	excitatory amino acid transporter 2 isoform 1
NM_011393.2	NP_035523.1	excitatory amino acid transporter 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	24307171	MGI
enables L-glutamate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	15009636	MGI
enables cysteine transmembrane transporter activity	IDA IDA: Inferred from direct assay	12614333	MGI
enables glutamate:sodium symporter activity	IDA IDA: Inferred from direct assay	7698742	MGI
enables high-affinity L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	9373176	MGI
enables monoatomic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	24307171	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	9373176	MGI
acts upstream of or within L-glutamate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	15140926	MGI
acts upstream of or within L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	7698742	MGI
acts upstream of or within L-glutamate transmembrane transport	IMP IMP: Inferred from mutant phenotype	15009636	MGI
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	9180080	MGI
involved in cellular response to cocaine	IDA IDA: Inferred from direct assay	27208619	MGI
acts upstream of or within cellular response to stimulus	IMP IMP: Inferred from mutant phenotype	16197522	MGI
involved in glutathione biosynthetic process	IDA IDA: Inferred from direct assay	12614333	MGI
acts upstream of or within monoatomic anion transmembrane transport	IDA IDA: Inferred from direct assay	24307171	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	9180080	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	9180080	MGI
involved in neurotransmitter reuptake	IDA IDA: Inferred from direct assay	25834045	MGI
involved in neurotransmitter reuptake	IMP IMP: Inferred from mutant phenotype	25834045	MGI
acts upstream of or within positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	16197522	MGI
acts upstream of or within response to amino acid	IMP IMP: Inferred from mutant phenotype	9180080	MGI
acts upstream of or within response to light stimulus	IMP IMP: Inferred from mutant phenotype	9539795	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	9180080	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	9180080	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	9180080	MGI
acts upstream of or within visual behavior	IMP IMP: Inferred from mutant phenotype	16197522	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in astrocyte projection	IDA IDA: Inferred from direct assay	25716834	MGI
located in axolemma	IDA IDA: Inferred from direct assay	9671661	MGI
located in axon	IDA IDA: Inferred from direct assay	9671661	MGI
located in cell body	IDA IDA: Inferred from direct assay	25716834	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25834045	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25834045	MGI
located in membrane	IDA IDA: Inferred from direct assay	29350434	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15187084	MGI
located in membrane raft	IGI IGI: Inferred from genetic interaction	20193040	MGI
located in neuron projection terminus	IDA IDA: Inferred from direct assay	12558972	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19364521	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	9373176	MGI
located in synapse	IDA IDA: Inferred from direct assay	12558972	MGI
located in vesicle	IDA IDA: Inferred from direct assay	19364521	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc1a2 Protein Structure

SDF

0
100
200
300
400
500
572 a.a.

Protein Preferred Names

Protein Names

excitatory amino acid transporter 2

EAAT2 variant mEAAT2/5UT2	EAAT2 variant mEAAT2/5UT5
glutamate transporter 1c	sodium-dependent glutamatespartate transporter 2
solute carrier family 1, member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13051	SLC1A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13052	Slc1a2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13053	Slc1a2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc1a2	NCBI	NCBI:6506

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