SLC1A2 - solute carrier family 1 member 2 Gene

Homo sapiens

Also known as GLT1; HBGT; DEE41; EAAT2; GLT-1; EIEE41

Gene ID: 6506 | Gene type: protein coding

About SLC1A2

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:35,251,205-35,420,507 (from NCBI)

This gene has 50 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 3 phenotypes. Restricted expression toward brain (RPKM 153.3).

Summary

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]

SLC1A2 Products(15)

mRNA	Protein	Name
XM_017018136.1	XP_016873625.1	excitatory amino acid transporter 2 isoform X3
XM_047427443.1	XP_047283399.1	excitatory amino acid transporter 2 isoform X5
NM_004171.4	NP_004162.2	excitatory amino acid transporter 2 isoform 1
XM_017018139.2	XP_016873628.1	excitatory amino acid transporter 2 isoform X7
XM_017018137.2	XP_016873626.1	excitatory amino acid transporter 2 isoform X5
XM_047427437.1	XP_047283393.1	excitatory amino acid transporter 2 isoform X2
XM_017018138.2	XP_016873627.1	excitatory amino acid transporter 2 isoform X5
XM_047427438.1	XP_047283394.1	excitatory amino acid transporter 2 isoform X5
NM_001195728.3	NP_001182657.1	excitatory amino acid transporter 2 isoform 2
XM_047427436.1	XP_047283392.1	excitatory amino acid transporter 2 isoform X1
XM_011520285.2	XP_011518587.1	excitatory amino acid transporter 2 isoform X4
NM_001252652.2	NP_001239581.1	excitatory amino acid transporter 2 isoform 2
XM_047427442.1	XP_047283398.1	excitatory amino acid transporter 2 isoform X5
XM_047427440.1	XP_047283396.1	excitatory amino acid transporter 2 isoform X5
XM_047427441.1	XP_047283397.1	excitatory amino acid transporter 2 isoform X6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	7521911	GOA
enables glutamate:sodium symporter activity	IDA IDA: Inferred from direct assay	15265858	GOA
enables high-affinity L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	26690923	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19527721	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-aspartate import across plasma membrane	IDA IDA: Inferred from direct assay	7521911	GOA
involved in L-aspartate import across plasma membrane	IDA IDA: Inferred from direct assay	7521911	GOA
involved in L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	7521911	GOA
involved in L-glutamate import across plasma membrane	IGI IGI: Inferred from genetic interaction	20193040	GOA
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	26690923	GOA
involved in protein homotrimerization	IDA IDA: Inferred from direct assay	15265858	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	21399631	GOA
part of membrane protein complex	IDA IDA: Inferred from direct assay	20193040	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	20193040	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	15265858	GOA
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	21258616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC1A2 Protein Structure

SDF

0
100
200
300
400
500
574 a.a.

Protein Preferred Names

Protein Names

excitatory amino acid transporter 2

excitotoxic amino acid transporter 2	glutamate transporter-1
glutamate/aspartate transporter II	human brain glutamate transporter
sodium-dependent glutamate/aspartate transporter 2	solute carrier family 1 (glial high affinity glutamate transporter), member 2

SLC1A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC1A2	P43004	MAPT	Homo sapiens	P10636	Anti Bait CoIP	19527721
Intra	SLC1A2	P43004	MAPT	Homo sapiens	P10636	Pull Down	19527721

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC1A2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82737	EAAT2 Antibody (YA2482)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Dicarboxylic Aminoaciduria

Glutamate-Aspartate Transport Defect	Dicarboxylicaminoaciduria
DCBXA	Renal Aminoacidurias

Trichotillomania

TTM	Hair-Pulling Syndrome
Compulsive Hair Plucking	Hair Pulling Disorder

Lateral Sclerosis

Primary Lateral Sclerosis	Adult-Onset Primary Lateral Sclerosis
Adult-Onset Pls	Motor Neuron Disease
Pls	Pls - [Primary Lateral Sclerosis]
Lateral Spinal Sclerosis	Lateral Complete Paralysis
Lateral Incomplete Paralysis	Lateral Paralysis

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Brain Edema

Intracranial Swelling	Wet Brain
Cerebral Edema

Hepatic Encephalopathy

Encephalopathy, Hepatic	Portal-Systemic Encephalopathy
Hepatoencephalopathy	He - [Hepatic Encephalopathy]
Hepatic Encephalopathy Nos	Hepatic Encephalopathy, Stage Unspecified
Hepatic Coma	Hepatocerebral Encephalopathy
Hepatocerebral Intoxication

Focal Epilepsy

Partial Epilepsy	Epilepsies, Partial
Localisation-Related Epilepsy

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Ischemia

Acute Coronary Syndrome

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Neuromyelitis Optica

Devic Disease	Devic Syndrome
Devic'S Disease	Neuromyelitis Optica Spectrum Disorder
Devic'S Syndrome	Devic'S Neuromyelitis Optica
Nmo	Nmo Spectrum Disorder
Neuromyelitis Optica Spectrum Disorders	Devic Neuromyelitis Optica
Optic-Spinal Ms	Opticospinal Ms
Nmosd	Opticospinal Multiple Sclerosis
Devic	Ophthalmoneuromyelitis
Optic Neuromyelitis	Optic Neuroencephalomyelopathy
Nmo - [Neuromyelitis Optica]	Optic Neuritis With Demyelination

Episodic Ataxia, Type 6

Episodic Ataxia Type 6	EA6
Episodic Ataxia 6	Ea-6
Ataxia, Episodic, Type 6

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Childhood Absence Epilepsy

Pyknolepsy	Petit Mal Epilepsy
Absence Seizures	Absence Seizure
Petit Mal Seizure	Absence Epilepsy, Childhood
Pykno-Epilepsy	Epilepsy, Absence
Absence Epilepsy	Pycnolepsy

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Toxic Encephalopathy

Neurotoxicity	Neurotoxicity Syndromes
Neurotoxicity Syndrome	Encephalopathy, Toxic

Migraine, Familial Hemiplegic, 2

FHM2	Mhp2
Migraine, Familial Basilar	Familial Hemiplegic Migraine 2
Familial Hemiplegic Migraine-2	Familiar Basilar Migraine
Migraine, Hemiplegic, Familial, Type 2

Ganglioglioma

Childhood Ganglioglioma	Adult Ganglioglioma
Cns Ganglioglioma	Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1

Guam Disease	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam
Als-Pdc	Lytico-Bodig Disease
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome	Parkinsonism-Dementia-Als Complex
Pdals	Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam
Parkinson-Dementia Complex Of Guam	G-Pdc
Guam Parkinsonism-Dementia Complex	ALS-PDC1
Als/Pdc Of Guam	Amyotrophic Lateral Sclerosis
Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1	Amyotrophic Lateral Sclerosis, Guam Form
Parkinsonian Disorders

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy	Non-Specific Eoee
Undetermined Eoee

Familial Hemiplegic Migraine

Hemiplegic Migraine, Familial	Hemiplegic-Ophthalmoplegic Migraine
Fhm	Hemiplegic Migraine Familial

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Episodic Ataxia

Isaacs Syndrome	Neuromyotonia
Isaacs' Syndrome	Acquired Neuromyotonia
Continuous Muscle Fiber Activity Syndrome	Quantal Squander Syndrome
Isaacs-Mertens Syndrome	Ea Syndrome
Episodic Ataxia Syndrome	Isaac Syndrome
Isaac'S-Merten'S Syndrome	Isaac-Mertens Syndrome
Peripheral Nerve Hyperexcitability	Ea
Ataxia, Episodic	Isaacs Neuromyotonia
Continuous Muscle Fibre Activity

Morphine Dependence

Encephalomalacia

Essential Tremor

Benign Essential Tremor	Familial Tremor
Hereditary Essential Tremor	Essential Hereditary Tremor
Shaky Hand Syndrome	Benign Essential Tremor Syndrome
Tremor Hereditary Essential	Essential Tremor, Susceptibility To
Tremor, Hereditary Essential

Alexander Disease

Alexander'S Disease	ALXDRD
Alexanders Leukodystrophy	Axd
Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia	Alx
Demyelinogenic Leukodystrophy	Dysmyelinogenic Leukodystrophy
Fibrinoid Degeneration Of Astrocytes	Leukodystrophy With Rosenthal Fibers
Alexander Disease Type Ii	Axd Type Ii
Alexander Disease Type I	Axd Type I
Alexanders Disease	Alexander'S Leukodystrophy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Wernicke Encephalopathy

Wernicke'S Encephalopathy	Wernicke'S Disease
Encephalopathy, Wernicke'S	Wernicke-Korsakoff Syndrome
Encephalopathy Due To Vitamin B1 Deficiency	Wernicke Disease
Wernicke Syndrome

Status Epilepticus

Grand Mal Status Epilepticus	Grand Mal Status
Gcse	Generalized Convulsive Status Epilepticus
Se	Epilepsy With Status Epilepticus

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Congenital Granular Cell Tumor

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Developmental And Epileptic Encephalopathy 41

DEE41	Epileptic Encephalopathy, Early Infantile, 41
Eiee41	Developmental And Epileptic Encephalopathy, 41
Early Infantile Epileptic Encephalopathy 41

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Developmental And Epileptic Encephalopathy 35

DEE35	Epileptic Encephalopathy, Early Infantile, 35
Eiee35	Developmental And Epileptic Encephalopathy, 35
Early Infantile Epileptic Encephalopathy 35	Itpa-Related Encephalopathy
Itpa-Related Lethal Infantile Neurological Disorder With Cataract And Cardiac Involvement	Martsolf-Like Syndrome

Developmental And Epileptic Encephalopathy 24

DEE24	Epileptic Encephalopathy, Early Infantile, 24
Eiee24	Developmental And Epileptic Encephalopathy, 24
Early Infantile Epileptic Encephalopathy 24	Encephalopathy, Epileptic, Early Infantile, Type 24

Huntington Disease

Huntington'S Disease	Huntington Chorea
HD	Huntington'S Chorea
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13051	SLC1A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13052	Slc1a2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13053	Slc1a2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC1A2	MGD	MGI:101931
Macaca mulatta	SLC1A2	VGNC	VGNC:77410
Bos taurus	SLC1A2	VGNC	VGNC:34712
Felis catus	SLC1A2	VGNC	VGNC:65230
Rattus norvegicus	SLC1A2	RGD	RGD:3697
Canis familiaris	SLC1A2	VGNC	VGNC:46262