2. Gene
  3. Snca - synuclein, alpha Gene

Snca - synuclein, alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NACP; alphaSYN; alpha-Syn

Gene ID: 20617 | Gene type: protein coding

About Snca

Chromosome 6: 60,708,559-60,806,839 reverse strand.GRCm39:CM000999.3

This gene has 4 transcripts (splice variants), 189 orthologues, 2 paralogues and is associated with 28 phenotypes. Biased expression in liver E14 (RPKM 144.4), liver E14.5 (RPKM 119.8) and 1 other tissues.

Summary

Enables arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein-containing complex assembly; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Located in several cellular components, including inclusion body; neuronal cell body; and synaptic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Snca Products(2)

mRNA Protein Name
NM_001042451.2 NP_001035916.1 alpha-synuclein
NM_009221.2 NP_033247.1 alpha-synuclein

Snca Protein Structure

Synuclein

Synuclein: pfam01387 (0 - 130)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

alpha-synuclein

non-A beta component of AD amyloid

non-A4 component of amyloid

Recombinant Snca Proteins

Cat. No. Product Name Accession Purity
HY-P70660 SNCA Protein, Mouse O55042-1(M1-A140) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135902A Synucleozid hydrochloride Inhibitor 98.23% Unkown
HY-135902 Synucleozid Inhibitor / Unkown
HY-RS13482 SNCA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13483 Snca Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13484 Snca Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Snca NCBI NCBI:6622