Snca - synuclein, alpha Gene

Mus musculus

Also known as NACP; alphaSYN; alpha-Syn

Gene ID: 20617 | Gene type: protein coding

About Snca

Chromosome 6: 60,708,559-60,806,839 reverse strand.GRCm39:CM000999.3

This gene has 4 transcripts (splice variants), 189 orthologues, 2 paralogues and is associated with 28 phenotypes. Biased expression in liver E14 (RPKM 144.4), liver E14.5 (RPKM 119.8) and 1 other tissues.

Summary

Enables arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein-containing complex assembly; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Located in several cellular components, including inclusion body; neuronal cell body; and synaptic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Snca Products(2)

mRNA	Protein	Name
NM_001042451.2	NP_001035916.1	alpha-synuclein
NM_009221.2	NP_033247.1	alpha-synuclein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arachidonate binding	IDA IDA: Inferred from direct assay	16734431	MGI
enables histone binding	IDA IDA: Inferred from direct assay	16959795	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	10978144	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17296554	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in SNARE complex assembly	IDA IDA: Inferred from direct assay	25246573	MGI
acts upstream of or within adult locomotory behavior	IGI IGI: Inferred from genetic interaction	18333965	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	16298531	MGI
acts upstream of or within chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	20974939	MGI
acts upstream of or within dopamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10707987	MGI
acts upstream of or within dopamine metabolic process	IGI IGI: Inferred from genetic interaction	15465911	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17610578	MGI
acts upstream of or within fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	14507911	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	17689254	MGI
acts upstream of or within membrane organization	IMP IMP: Inferred from mutant phenotype	14507911	MGI
acts upstream of or within microglial cell activation	IMP IMP: Inferred from mutant phenotype	17035541	MGI
acts upstream of or within mitochondrial ATP synthesis coupled electron transport	IMP IMP: Inferred from mutant phenotype	16260631	MGI
acts upstream of or within mitochondrial membrane organization	IMP IMP: Inferred from mutant phenotype	16260631	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	16269331	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	16269331	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15380020	MGI
acts upstream of neurotransmitter secretion	IDA IDA: Inferred from direct assay	15510220	MGI
acts upstream of or within neutral lipid metabolic process	IMP IMP: Inferred from mutant phenotype	17250686	MGI
acts upstream of or within phospholipid metabolic process	IMP IMP: Inferred from mutant phenotype	15938614	MGI
acts upstream of or within positive regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	15510220	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	21127069	MGI
acts upstream of or within positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	15579163	MGI
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	25246573	MGI
acts upstream of or within regulation of acyl-CoA biosynthetic process	IDA IDA: Inferred from direct assay	16734431	MGI
acts upstream of or within regulation of acyl-CoA biosynthetic process	IMP IMP: Inferred from mutant phenotype	16636270	MGI
acts upstream of or within regulation of dopamine secretion	IGI IGI: Inferred from genetic interaction	18333965	MGI
acts upstream of or within regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	17689254	MGI
acts upstream of or within regulation of locomotion	IMP IMP: Inferred from mutant phenotype	10707987	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	15510220	MGI
acts upstream of or within regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	17035541	MGI
NOT acts upstream of or within regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15380020	MGI
acts upstream of or within regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17610578	MGI
acts upstream of or within regulation of neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	18333965	MGI
acts upstream of or within regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	10707987	MGI
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	25043722	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	10707987	MGI
acts upstream of or within synapse organization	IGI IGI: Inferred from genetic interaction	20974939	MGI
acts upstream of or within synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	10707987	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	25009269	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	18980610	MGI
acts upstream of or within synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	12388586	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	17296554	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17475220	MGI
located in cytoskeleton	IDA IDA: Inferred from direct assay	17077307	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18980610	MGI
located in inclusion body	IDA IDA: Inferred from direct assay	17222866	MGI
located in neuronal cell body	IMP IMP: Inferred from mutant phenotype	26203154	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16959795	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17475220	MGI
located in synapse	IDA IDA: Inferred from direct assay	10964942	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	28052246	MGI
is active in synaptic vesicle membrane	IEP IEP: Inferred from expression pattern	28052246	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Snca Protein Structure

Synuclein

0
100
140 a.a.

Protein Preferred Names

Protein Names

alpha-synuclein

non-A beta component of AD amyloid

non-A4 component of amyloid

Snca Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Snca	O55042	Sod1	Mus musculus	P08228	Anti Bait CoIP	26643113
Intra	Snca	O55042	Rab8a	Mus musculus	P55258	Anti Bait CoIP	24983211
Intra	Snca	O55042	Slc6a3	Mus musculus	Q61327	IF	22163275
Intra	Snca	O55042	Slc6a3	Mus musculus	Q61327	Anti Bait CoIP	22163275

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Snca Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70660	SNCA Protein, Mouse	O55042-1(M1-A140)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135902A	Synucleozid hydrochloride	Inhibitor	98.23%	Unkown
HY-135902	Synucleozid	Inhibitor	/	Unkown
HY-RS13482	SNCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13483	Snca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13484	Snca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990898	Amlenetug		/	Unkown
HY-P990922	Indenebart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snca	NCBI	NCBI:6622

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