2. Gene
  3. Plk2 - polo like kinase 2 Gene

Plk2 - polo like kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Snk

Gene ID: 20620 | Gene type: protein coding

About Plk2

Chromosome 13: 110,531,580-110,537,378 forward strand.GRCm39:CM001006.3

This gene has 5 transcripts (splice variants), 221 orthologues, 4 paralogues and is associated with 11 phenotypes. Broad expression in CNS E18 (RPKM 28.3), cortex adult (RPKM 24.4) and 22 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process in bone marrow cell; negative regulation of cellular senescence; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within mitotic cell cycle and negative regulation of apoptotic process. Located in chromatin. Is expressed in several structures, including alimentary system; hindlimb interdigital region; integumental system; nervous system; and skeleton. Orthologous to human PLK2 (polo like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Plk2 Products(1)

mRNA Protein Name
NM_152804.2 NP_690017.2 serine/threonine-protein kinase PLK2

Plk2 Protein Structure

STKc_PLK2

STKc_PLK2: cd14188 (76 - 330)

POLO_box_1

POLO_box_1: cd13118 (499 - 584)

POLO_box_2

POLO_box_2: cd13117 (597 - 678)

  • 0
  • 200
  • 400
  • 600
  • 682 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK2

PLK-2

serine/threonine-protein kinase SNK

serum-inducible kinase

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.41% Yes
HY-12137A Volasertib trihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12037A Rigosertib Inhibitor 98.35% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100789 ON1231320 Inhibitor 99.24% Unkown
HY-108597 TC-S 7005 Inhibitor 99.56% Unkown
HY-12134 Poloxin Inhibitor 98.01% Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk2 NCBI NCBI:10769