SLC36A1 - solute carrier family 36 member 1 Gene

Homo sapiens

Also known as Dct1; PAT1; LYAAT1; TRAMD3

Gene ID: 206358 | Gene type: protein coding

About SLC36A1

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,344,596-151,556,085 (from NCBI)

This gene has 11 transcripts (splice variants), 249 orthologues and 15 paralogues. Broad expression in duodenum (RPKM 7.4), small intestine (RPKM 6.6) and 20 other tissues.

Summary

This gene encodes a member of the eukaryote-specific amino acid/Auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

SLC36A1 Products(4)

mRNA	Protein	Name
NM_001308150.2	NP_001295079.1	proton-coupled amino acid transporter 1 isoform b
NM_001308151.2	NP_001295080.1	proton-coupled amino acid transporter 1 isoform c
NM_001349740.2	NP_001336669.1	proton-coupled amino acid transporter 1 isoform d
NM_078483.4	NP_510968.2	proton-coupled amino acid transporter 1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables alanine transmembrane transporter activity	IDA IDA: Inferred from direct assay	19074966	GOA
enables amino acid:proton symporter activity	IDA IDA: Inferred from direct assay	12527723	GOA
enables proline:proton symporter activity	IDA IDA: Inferred from direct assay	12527723	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables taurine transmembrane transporter activity	IDA IDA: Inferred from direct assay	19074966	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in alanine transport	IDA IDA: Inferred from direct assay	19074966	GOA
involved in amino acid import across plasma membrane	IDA IDA: Inferred from direct assay	19074966	GOA
involved in taurine transmembrane transport	IDA IDA: Inferred from direct assay	19074966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC36A1 Protein Structure

Aa_trans

0
100
200
300
400
476 a.a.

Protein Preferred Names

Protein Names

proton-coupled amino acid transporter 1

lysosomal amino acid transporter 1

Related Diseases

Diseases

Alias

Iminoglycinuria

Iminoglycinuria, Digenic

Hyperglycinuria

Glycinuria With Or Without Oxalate Urolithiasis	Glycinuria With Or Without Oxalate Nephrolithiasis
Iminoglycinuria Type Ii	HG

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Digenic Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2368	Arecaidine	Inhibitor	99.58%	Unkown
HY-N2368A	Arecaidine hydrochloride	Inhibitor	98.00%	Unkown
HY-N2368B	Arecaidine hydrobromide	Inhibitor	/	Unkown
HY-RS13210	SLC36A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC36A1	VGNC	VGNC:102322
Canis familiaris	SLC36A1	VGNC	VGNC:46382
Macaca mulatta	SLC36A1	VGNC	VGNC:77509
Mus musculus	SLC36A1	MGD	MGI:2445299
Bos taurus	SLC36A1	VGNC	VGNC:34838
Rattus norvegicus	SLC36A1	RGD	RGD:619801

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