2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Arecaidine

Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake.

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Arecaidine Chemical Structure

Arecaidine Chemical Structure

CAS No. : 499-04-7

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5 mg USD 130 In-stock
10 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Arecaidine:

Arecaidine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Molecular Weight

141.17

Formula

C7H11NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CCCN(C)C1)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1770.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.0837 mL 35.4183 mL 70.8366 mL
5 mM 1.4167 mL 7.0837 mL 14.1673 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (708.37 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.58%

COA (246 KB) HNMR (253 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.0837 mL 35.4183 mL 70.8366 mL 177.0915 mL
5 mM 1.4167 mL 7.0837 mL 14.1673 mL 35.4183 mL
10 mM 0.7084 mL 3.5418 mL 7.0837 mL 17.7091 mL
15 mM 0.4722 mL 2.3612 mL 4.7224 mL 11.8061 mL
20 mM 0.3542 mL 1.7709 mL 3.5418 mL 8.8546 mL
25 mM 0.2833 mL 1.4167 mL 2.8335 mL 7.0837 mL
30 mM 0.2361 mL 1.1806 mL 2.3612 mL 5.9030 mL
40 mM 0.1771 mL 0.8855 mL 1.7709 mL 4.4273 mL
50 mM 0.1417 mL 0.7084 mL 1.4167 mL 3.5418 mL
60 mM 0.1181 mL 0.5903 mL 1.1806 mL 2.9515 mL
80 mM 0.0885 mL 0.4427 mL 0.8855 mL 2.2136 mL
100 mM 0.0708 mL 0.3542 mL 0.7084 mL 1.7709 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Arecaidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arecaidine499-04-7GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorβ-alanineuptakealkaloidnervousL-prolinePAT1SLC36A1Inhibitorinhibitorinhibit

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