2. Gene
  3. Spint2 - serine protease inhibitor, Kunitz type 2 Gene

Spint2 - serine protease inhibitor, Kunitz type 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HAI-2

Gene ID: 20733 | Gene type: protein coding

About Spint2

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within basement membrane organization; chordate embryonic development; and establishment or maintenance of cell polarity. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Apr 2022]

Spint2 Products(2)

mRNA Protein Name
NM_001082548.1 NP_001076017.1 kunitz-type protease inhibitor 2 isoform b precursor
NM_011464.2 NP_035594.1 kunitz-type protease inhibitor 2 isoform a precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within basement membrane organization IMP
IMP: Inferred from mutant phenotype
19592578 MGI
acts upstream of or within epithelial cell morphogenesis involved in placental branching IGI
IGI: Inferred from genetic interaction
19592578 MGI
acts upstream of or within epithelial cell morphogenesis involved in placental branching IMP
IMP: Inferred from mutant phenotype
19592578 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
19592578 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
19592578 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
19592578 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kunitz-type protease inhibitor 2

hepatocyte growth factor activator inhibitor type 2

Recombinant Spint2 Proteins

Cat. No. Product Name Accession Purity
HY-P76964 HAI-2 Protein, Mouse (HEK293, His) Q9WU03-2 /NP_001076017.1 (A28-K140) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13686 SPINT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spint2 NCBI NCBI:10653