2. Gene
  3. Btla - B and T lymphocyte associated Gene

Btla - B and T lymphocyte associated Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as A630002H24

Gene ID: 208154 | Gene type: protein coding

About Btla

Summary

Enables signaling receptor activity. Acts upstream of or within immune response-regulating cell surface receptor signaling pathway; negative regulation of B cell proliferation; and negative regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is integral component of plasma membrane. Orthologous to human BTLA (B and T lymphocyte associated). [provided by Alliance of Genome Resources, Apr 2022]

Btla Products(2)

mRNA Protein Name
NM_001037719.2 NP_001032808.2 B- and T-lymphocyte attenuator isoform 1 precursor
NM_177584.3 NP_808252.1 B- and T-lymphocyte attenuator isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12796776 MGI
enables signaling receptor activity IGI
IGI: Inferred from genetic interaction
12920180 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
15568026 MGI
acts upstream of or within immune response-regulating cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15568026 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12796776 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
12796776 MGI
acts upstream of or within negative regulation of alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
15568026 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15568026 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12796776 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B- and T-lymphocyte attenuator

B- and T-lymphocyte-associated protein

Recombinant Btla Proteins

Cat. No. Product Name Accession Purity
HY-P75467 BTLA/CD272 Protein, Mouse (HEK293, hFc) Q32MV9 (E30-G176) ≥95%
HY-P78246 BTLA/CD272 Protein, Mouse (HEK293, His) Q32MV9 (E30-G176) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108813 Belatacept Inhibitor ≥98.0% Unkown
Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99961 Tifcemalimab Inhibitor 95.00% Phase 3
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-159885 MG-B-28 / Unkown
HY-RS01669 BTLA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Btla NCBI NCBI:151888
Macaca fascicularis Btla NCBI NCBI:102144877
Rattus norvegicus Btla NCBI NCBI:407756
Macaca mulatta Btla NCBI NCBI:708202