Stat5b - signal transducer and activator of transcription 5B Gene

Mus musculus

Gene ID: 20851 | Gene type: protein coding

About Stat5b

Chromosome 11: 100,671,557-100,741,550 reverse strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 286 orthologues, 6 paralogues and is associated with 26 phenotypes. Ubiquitous expression in thymus adult (RPKM 41.1), ovary adult (RPKM 18.1) and 27 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in cellular response to growth factor stimulus; growth hormone receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; positive regulation of defense response; and positive regulation of lymphocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]

Stat5b Products(3)

mRNA	Protein	Name
NM_001113563.2	NP_001107035.1	signal transducer and activator of transcription 5B
NM_011489.3	NP_035619.3	signal transducer and activator of transcription 5B
NM_001362682.1	NP_001349611.1	signal transducer and activator of transcription 5B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10485657	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19666510	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19666510	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17666591	MGI
enables protein dimerization activity	IDA IDA: Inferred from direct assay	20639532	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell differentiation	IGI IGI: Inferred from genetic interaction	10979977	MGI
acts upstream of or within Peyer's patch development	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within T cell differentiation in thymus	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within T cell homeostasis	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of activated T cell proliferation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	10485657	MGI
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	20639532	MGI
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	10485657	MGI
acts upstream of or within development of secondary female sexual characteristics	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of or within development of secondary male sexual characteristics	IGI IGI: Inferred from genetic interaction	9630227	MGI
acts upstream of or within development of secondary male sexual characteristics	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within female pregnancy	IGI IGI: Inferred from genetic interaction	15471942	MGI
acts upstream of or within female pregnancy	IMP IMP: Inferred from mutant phenotype	15471942	MGI
acts upstream of gamma-delta T cell differentiation	IGI IGI: Inferred from genetic interaction	15294943	MGI
involved in growth hormone receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	8923468	MGI
acts upstream of interleukin-2 production	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of or within lipid storage	IGI IGI: Inferred from genetic interaction	9630227	MGI
acts upstream of or within luteinization	IGI IGI: Inferred from genetic interaction	9630227	MGI
acts upstream of lymphocyte differentiation	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within mast cell migration	IMP IMP: Inferred from mutant phenotype	24068671	MGI
acts upstream of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of myeloid cell apoptotic process	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within natural killer cell differentiation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of natural killer cell proliferation	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within negative regulation of erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within positive regulation of B cell differentiation	IGI IGI: Inferred from genetic interaction	10979977	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within positive regulation of gamma-delta T cell differentiation	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within positive regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within positive regulation of interleukin-2 production	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within positive regulation of lymphocyte differentiation	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within positive regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	9630227	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of or within positive regulation of natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within positive regulation of natural killer cell proliferation	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19666510	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20639532	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10485657	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of or within progesterone metabolic process	IGI IGI: Inferred from genetic interaction	15471942	MGI
acts upstream of or within regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	11706048	MGI
acts upstream of or within regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	11706048	MGI
involved in regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	18648510	MGI
acts upstream of or within regulation of steroid metabolic process	IGI IGI: Inferred from genetic interaction	15471942	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within response to interleukin-15	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within response to interleukin-2	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within response to interleukin-4	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within sex differentiation	IMP IMP: Inferred from mutant phenotype	17412818	MGI
acts upstream of positive effect taurine metabolic process	IGI IGI: Inferred from genetic interaction	18648510	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10485657	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9630227	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12634107	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12147240	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat5b Protein Structure

STAT_int

STAT5_CCD

STAT5_DBD

SH2_STAT5b

0
200
400
600
786 a.a.

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 5B

mammary gland factor STAT5B

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148813	AK-2292		99.73%	Unkown
HY-136546	Stafia-1	Inhibitor	99.37%	Unkown
HY-112647	Stafib-1	Inhibitor	≥98.0%	Unkown
HY-19527	IST5-002		99.36%	Unkown
HY-112648	Stafib-2	Inhibitor	98.42%	Unkown
HY-112649	Pomstafib-2		99.37%	Unkown
HY-170837	STAT5-IN-3	Inhibitor	/	Unkown
HY-RS13893	STAT5B Human Pre-designed siRNA Set A		/	Unkown
HY-RS13894	Stat5b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13895	Stat5b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat5b	NCBI	NCBI:6777

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