Stat6 - signal transducer and activator of transcription 6 Gene

Mus musculus

Gene ID: 20852 | Gene type: protein coding

About Stat6

Chromosome 10: 127,478,855-127,496,826 forward strand.GRCm39:CM001003.3

This gene has 5 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 71 phenotypes. Ubiquitous expression in spleen adult (RPKM 35.4), thymus adult (RPKM 34.3) and 24 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in interleukin-4-mediated signaling pathway and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; alimentary system; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]

Stat6 Products(1)

mRNA	Protein	Name
NM_009284.2	NP_033310.2	signal transducer and transcription activator 6

Stat6 Protein Structure

STAT_int

STAT6_CCD

STAT6_DBD

SH2_STAT6

STAT6_C

0
200
400
600
837 a.a.

Protein Preferred Names

Protein Names

signal transducer and transcription activator 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100614	AS1517499	Inhibitor	99.17%	Unkown
HY-134772	AS1810722	Inhibitor	98.14%	Unkown
HY-134771	YM-341619	Inhibitor	99.06%	Unkown
HY-N0407	Picroside I	Inhibitor	99.55%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat6	NCBI	NCBI:6778

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