Stat6 - signal transducer and activator of transcription 6 Gene

Mus musculus

Gene ID: 20852 | Gene type: protein coding

About Stat6

Chromosome 10: 127,478,855-127,496,826 forward strand.GRCm39:CM001003.3

This gene has 5 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 71 phenotypes. Ubiquitous expression in spleen adult (RPKM 35.4), thymus adult (RPKM 34.3) and 24 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in interleukin-4-mediated signaling pathway and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; alimentary system; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]

Stat6 Products(1)

mRNA	Protein	Name
NM_009284.2	NP_033310.2	signal transducer and transcription activator 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10490661	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16537510	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15659391	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T-helper 1 cell lineage commitment	IGI IGI: Inferred from genetic interaction	20706986	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	31408278	MGI
involved in interleukin-4-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17210636	MGI
acts upstream of isotype switching to IgE isotypes	IGI IGI: Inferred from genetic interaction	10490661	MGI
acts upstream of or within mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	22588720	MGI
acts upstream of or within mammary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	22588720	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20956546	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18997793	MGI
acts upstream of or within negative regulation of type 2 immune response	IGI IGI: Inferred from genetic interaction	10438949	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24906148	MGI
acts upstream of or within positive regulation of isotype switching to IgE isotypes	IGI IGI: Inferred from genetic interaction	10490661	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9110977	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21217760	MGI
acts upstream of or within regulation of mast cell proliferation	IDA IDA: Inferred from direct assay	12093868	MGI
acts upstream of or within signal transduction	IMP IMP: Inferred from mutant phenotype	17658279	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	15187136	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12093868	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12093868	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat6 Protein Structure

STAT_int

STAT6_CCD

STAT6_DBD

SH2_STAT6

STAT6_C

0
200
400
600
837 a.a.

Protein Preferred Names

Protein Names

signal transducer and transcription activator 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100614	AS1517499	Inhibitor	99.17%	Unkown
HY-134772	AS1810722	Inhibitor	98.14%	Unkown
HY-134771	YM-341619	Inhibitor	99.06%	Unkown
HY-N0407	Picroside I	Inhibitor	99.55%	Unkown
HY-113509B	15(R)-Lipoxin A4	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat6	NCBI	NCBI:6778

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