STAT6 - signal transducer and activator of transcription 6 Gene

Homo sapiens

Also known as STAT6B; STAT6C; D12S1644; IL-4-STAT

Gene ID: 6778 | Gene type: protein coding

About STAT6

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,095,408-57,111,362 (from NCBI)

This gene has 25 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 75 phenotypes. Ubiquitous expression in spleen (RPKM 48.4), skin (RPKM 47.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

STAT6 Products(11)

mRNA	Protein	Name
XM_047429477.1	XP_047285433.1	signal transducer and activator of transcription 6 isoform X3
NM_001178078.2	NP_001171549.1	signal transducer and activator of transcription 6 isoform 1
NM_001178081.2	NP_001171552.1	signal transducer and activator of transcription 6 isoform 2
XM_047429474.1	XP_047285430.1	signal transducer and activator of transcription 6 isoform X1
XM_047429473.1	XP_047285429.1	signal transducer and activator of transcription 6 isoform X1
NR_033659.2
NM_003153.5	NP_003144.3	signal transducer and activator of transcription 6 isoform 1
XM_047429476.1	XP_047285432.1	signal transducer and activator of transcription 6 isoform X2
NM_001178079.2	NP_001171550.1	signal transducer and activator of transcription 6 isoform 1
NM_001178080.2	NP_001171551.1	signal transducer and activator of transcription 6 isoform 2
XM_047429475.1	XP_047285431.1	signal transducer and activator of transcription 6 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8810328	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8816495	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	36884218	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8810328	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22000020	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8816495	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	17210636	GOA
enables transcription coactivator binding	EXP EXP: Inferred from Experiment	29203888	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	12574355	GOA
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	36884218	GOA
involved in interleukin-4-mediated signaling pathway	IDA IDA: Inferred from direct assay	7760829	GOA
involved in interleukin-4-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12574355	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8810328	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12574355	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	22000020	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	7694370	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	36758835	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAT6 Protein Structure

STAT_int

STAT_alpha

STAT_bind

SH2

STAT6_C

0
200
400
600
800
847 a.a.

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 6

STAT, interleukin4-induced	signal transducer and activator of transcription 6, interleukin-4 induced
transcription factor IL-4 STAT

STAT6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STAT6	P42226	TBK1	Homo sapiens	Q9UHD2	Anti Bait CoIP	22000020
Intra	STAT6	P42226	STING1	Homo sapiens	Q86WV6	Anti Bait CoIP	22000020
Intra	STAT6	P42226	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	22000020
Intra	STAT6	P42226	NMI	Homo sapiens	Q13287	Y2H Array	20211142
Intra	STAT6	P42226	IL4R	Homo sapiens	P24394	FPS	8816495
Intra	STAT6	P42226	TBK1	Homo sapiens	Q9UHD2	Protein Kinase Assay	22000020
Intra	STAT6	P42226	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	22000020
Intra	STAT6	P42226	IL4R	Homo sapiens	P24394	Pull Down	9392697

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STAT6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71337	STAT6 Protein, Human (His)	P42226 (S627-S837)	≥95%

Related Diseases

Diseases

Alias

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Ige Responsiveness, Atopic

ATOPY	Atopy, Susceptibility To
Ige, Elevated Level Of	IGER
Immunoglobulin E, Basic Level Of, In Serum	Ige, Level Of
Igel	Ige Response Underlying Allergic Asthma And Rhinitis
Atopic Hypersensitivity	Immediate Hypersensitivity

Colitis

Nasal Cavity Disease

Disorder Of Nasal Cavity

Secondary Hypertrophic Osteoarthropathy

Osteoarthropathy, Secondary Hypertrophic	Bamberger-Marie Disease
Hpoa - Hypertrophic Pulmonary Osteoarthropathy	Hypertrophic Pulmonary Osteoarthropathy
Marie Bamberger Disease

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Severe Combined Immunodeficiency, X-Linked

X-Linked Severe Combined Immunodeficiency	SCIDX1
XSCID	Scidx
X-Linked Scid	X-Scid
Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative	Scid, X-Linked
Immunodeficiency 4	Imd4
Gamma Chain Deficiency	Scid-X1
X-Linked Combined Immunodeficiency Diseases	Thymic Epithelial Hypoplasia
Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency	Severe Combined Immunodeficiency T- B+, X-Linked
Il2rg Scid, T- B+ Nk-	T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
T-B+ Scid Due To Gamma Chain Deficiency	T-B+ Severe Combined Immunodeficiency, X-Linked
Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative	Agammaglobulinemia Swiss Type
Scid X-Linked	Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative
Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative	Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Spindle Cell Lipoma

Vagina Sarcoma

Sarcoma Of The Vagina

Vaginal Sarcoma

Potter'S Syndrome

Potter Syndrome	Potter Sequence
Oligohydramnios Sequence	Congenital Absence Of Kidneys Syndrome

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Vascular Cancer

Blood Vessel Tumors	Malignant Vascular Neoplasm
Renal Vein Leiomyosarcoma	Vascular Neoplasms
Blood Vessel Neoplasm	Blood Vessel Tumor
Blood Vessel Tumour Disorder	Haemangiomatous Tumour
Leiomyosarcoma Of The Renal Vein	Malignant Great Vessel Tumor
Malignant Tumor Of Pulmonary Artery	Malignant Tumor Of Pulmonary Vein
Malignant Vascular Tumor	Neoplasm Of Great Vessel
Pulmonary Artery Malignant Neoplasm	Pulmonary Vein Malignant Neoplasm
Vascular Tissue Neoplasm	Vascular Tumors
Blood Vessel Cancer	Neoplasms, Vascular Tissue
Malignant Neoplasm Of Great Vessels

Contact Dermatitis

Contact Dermatitis/Eczema	Contact Eczema
Dermatitis Venenata	Dermatitis, Venenata
Dermatitis Contact	Dermatitis, Contact

Cardiomyopathy, Familial Restrictive, 1

RCM1	Restrictive Cardiomyopathy 1
Rcm	Familial Restrictive Cardiomyopathy 1
Cardiomyopathy, Familial Restrictive 1	Cardiomyopathy, Restrictive, Familial, Type 1
Rcm-1

Pericytoma With T(7;12)

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Neurofibroma Of The Heart

Neurofibroma Of Heart

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Carbapenem Allergy

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Trigeminal Nerve Neoplasm

Neoplasm Of Trigeminal Nerve

Tumor Of Trigeminal Nerve

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Esophagitis

Acute Esophagitis

Myofibroma

Lipoleiomyoma	Uterine Fibroids
Solitary Myofibromatosis	Myolipoma

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Dlbcl Abc Type

Benign Fibrous Mesothelioma

Fibrous Mesothelioma, Benign	Localized Benign Fibrous Mesothelioma
Solitary Fibrous Tumor, Pleural	Pleural Solitary Fibrous Tumor
Solitary Fibrous Tumor

Vaginal Endometrial Stromal Sarcoma

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Phenytoin Allergy

Dilantin Allergy

Prostate Signet Ring Cell Adenocarcinoma

Prostate Signet Ring Cell Carcinoma	Signet Ring Cell Carcinoma Of Prostate
Acinar Prostate Adenocarcinoma, Signet Ring Variant

Meninges Hemangiopericytoma

Hemangiopericytoma Of Meninges

Meningeal Hemangiopericytoma

Respiratory Allergy

Airway Allergy

Hemangiopericytoma, Malignant

Hemangiopericytoma	Haemangiopericytic Meningioma
Malignant Hemangiopericytoma	Solitary Fibrous Tumor

Liposarcoma

Lipomatous Cancer

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor	Mesenchymal Tumor
Mesenchymal Tumors

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Testicular Fibroma

Fibrous Meningioma

Fibroblastic Meningioma

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Neurilemmoma Of The Fifth Cranial Nerve

Trigeminal Schwannoma

Trigeminal Neurilemmoma

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Trichinosis

Trichinellosis	Human Trichinellosis
Trichiniasis	Trichinella Spiralis Infection
Infection With Trichinella	Trichinelliasis
Trichinella Spiralis Infestation

Inflammatory Bowel Disease 24

IBD24

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Inflammatory Bowel Disease 2

IBD2

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Small Cell Sarcoma

Sarcoma, Small Cell

Pseudosarcomatous Fibromatosis

Nodular Fasciitis	Pseudosarcomatous Fasciitis
Fasciitis - Nodular	Fasciitis Nodular

Chronic Asthma

Perivascular Tumor

Malignant Perivascular Cancer

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Schistosomiasis

Katayama Fever	Bilharzia
Bilharziasis	Schistosomiasis Mansoni
Blood Fluke	Schistosoma Mansoni Infection
Snail Fever	Acute Schistosomiasis
Schistosomiasis Manson	Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis]
Intestinal Schistosomiasis Nos	Intestinal Schistosomiasis
Egyptian Splenomegaly	Bilharziasis Of Intestine
Schistosomal Dysentery	Schistosomiasis Of Colon
Asiatic Schistosomiasis	Eastern Schistosomiasis
Schistosoma Japonicum Infection	Schistosomiasis Japonicum
Katayama Disease	Katayama Syndrome
Oriental Schistosomiasis

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100614	AS1517499	Inhibitor	99.17%	Unkown
HY-134772	AS1810722	Inhibitor	98.14%	Unkown
HY-134771	YM-341619	Inhibitor	99.06%	Unkown
HY-N0407	Picroside I	Inhibitor	99.55%	Unkown
HY-113509B	15(R)-Lipoxin A4	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STAT6	VGNC	VGNC:35374
Felis catus	STAT6	VGNC	VGNC:65763
Rattus norvegicus	STAT6	RGD	RGD:1309063
Canis familiaris	STAT6	VGNC	VGNC:46892
Mus musculus	STAT6	MGD	MGI:103034
Macaca mulatta	STAT6	VGNC	VGNC:77908
Others	STAT6	NCBI